Literature DB >> 17931679

Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors.

Katherine Luby-Phelps1, Joseph Fogerty, Sheila A Baker, Gregory J Pazour, Joseph C Besharse.   

Abstract

Intraflagellar transport (IFT) of a approximately 17S particle containing at least 16 distinct polypeptides is required for the assembly and maintenance of cilia and flagella. Although both genetic and biochemical evidence suggest a role for IFT in vertebrate photoreceptors, the spatial distribution of IFT proteins within photoreceptors remains poorly defined. We have evaluated the distribution of 4 IFT proteins using a combination of immunocytochemistry and rod-specific overexpression of GFP tagged IFT proteins. Endogenous IFT proteins are most highly concentrated within the inner segment, around the basal body, and within the outer segment IFT proteins are localized in discrete particles along the entire length of the axoneme. IFT52-GFP and IFT57-GFP mimicked this pattern in transgenic Xenopus.

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Year:  2007        PMID： 17931679      PMCID： PMC2276311          DOI： 10.1016/j.visres.2007.08.022

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  50 in total

1.  Isolation of a zebrafish rod opsin promoter to generate a transgenic zebrafish line expressing enhanced green fluorescent protein in rod photoreceptors.

Authors:  B N Kennedy; T S Vihtelic; L Checkley; K T Vaughan; D R Hyde
Journal:  J Biol Chem       Date:  2001-01-18       Impact factor: 5.157

2.  Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles.

Authors:  J A Deane; D G Cole; E S Seeley; D R Diener; J L Rosenbaum
Journal:  Curr Biol       Date:  2001-10-16       Impact factor: 10.834

3.  Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation.

Authors:  Maxim Sokolov; Arkady L Lyubarsky; Katherine J Strissel; Andrey B Savchenko; Viktor I Govardovskii; Edward N Pugh; Vadim Y Arshavsky
Journal:  Neuron       Date:  2002-03-28       Impact factor: 17.173

Review 4.  Intraflagellar transport.

Authors:  Joel L Rosenbaum; George B Witman
Journal:  Nat Rev Mol Cell Biol       Date:  2002-11       Impact factor: 94.444

5.  Resetting the circadian clock in cultured Xenopus eyecups: regulation of retinal melatonin rhythms by light and D2 dopamine receptors.

Authors:  G M Cahill; J C Besharse
Journal:  J Neurosci       Date:  1991-10       Impact factor: 6.167

6.  A motility in the eukaryotic flagellum unrelated to flagellar beating.

Authors:  K G Kozminski; K A Johnson; P Forscher; J L Rosenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

7.  Arrestin migrates in photoreceptors in response to light: a study of arrestin localization using an arrestin-GFP fusion protein in transgenic frogs.

Authors:  James J Peterson; Beatrice M Tam; Orson L Moritz; Charles L Shelamer; Donald R Dugger; J Hugh McDowell; Paul A Hargrave; David S Papermaster; W Clay Smith
Journal:  Exp Eye Res       Date:  2003-05       Impact factor: 3.467

8.  Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation.

Authors:  Courtney J Haycraft; Jenny C Schafer; Qihong Zhang; Patrick D Taulman; Bradley K Yoder
Journal:  Exp Cell Res       Date:  2003-04-01       Impact factor: 3.905

9.  The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance.

Authors:  Gregory J Pazour; Sheila A Baker; James A Deane; Douglas G Cole; Bethany L Dickert; Joel L Rosenbaum; George B Witman; Joseph C Besharse
Journal:  J Cell Biol       Date:  2002-03-26       Impact factor: 10.539

10.  Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans.

Authors:  D Signor; K P Wedaman; J T Orozco; N D Dwyer; C I Bargmann; L S Rose; J M Scholey
Journal:  J Cell Biol       Date:  1999-11-01       Impact factor: 10.539
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  21 in total

Review 1.  Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy.

Authors:  Norann A Zaghloul; Nicholas Katsanis
Journal:  J Clin Invest       Date:  2009-03-02       Impact factor: 14.808

Review 2.  Light-dependent compartmentalization of transducin in rod photoreceptors.

Authors:  Nikolai O Artemyev
Journal:  Mol Neurobiol       Date:  2008-04-19       Impact factor: 5.590

3.  Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Authors:  Cheryl J Wiens; Yufeng Tong; Muneer A Esmail; Edwin Oh; Jantje M Gerdes; Jihong Wang; Wolfram Tempel; Jerome B Rattner; Nicholas Katsanis; Hee-Won Park; Michel R Leroux
Journal:  J Biol Chem       Date:  2010-03-05       Impact factor: 5.157

4.  Photoreceptor structure and development analyses using GFP transgenes.

Authors:  Brian D Perkins; James M Fadool
Journal:  Methods Cell Biol       Date:  2010       Impact factor: 1.441

5.  Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.

Authors:  John F Dishinger; Hooi Lynn Kee; Paul M Jenkins; Shuling Fan; Toby W Hurd; Jennetta W Hammond; Yen Nhu-Thi Truong; Ben Margolis; Jeffrey R Martens; Kristen J Verhey
Journal:  Nat Cell Biol       Date:  2010-06-06       Impact factor: 28.824

6.  Intraflagellar transport molecules in ciliary and nonciliary cells of the retina.

Authors:  Tina Sedmak; Uwe Wolfrum
Journal:  J Cell Biol       Date:  2010-04-05       Impact factor: 10.539

7.  Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.

Authors:  Pamela R Pretorius; Lisa M Baye; Darryl Y Nishimura; Charles C Searby; Kevin Bugge; Baoli Yang; Robert F Mullins; Edwin M Stone; Val C Sheffield; Diane C Slusarski
Journal:  PLoS Genet       Date:  2010-03-19       Impact factor: 5.917

Review 8.  Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors.

Authors:  Christine Insinna; Joseph C Besharse
Journal:  Dev Dyn       Date:  2008-08       Impact factor: 3.780

9.  Early defects in photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 Intraflagellar Transport mutants.

Authors:  Sujita Sukumaran; Brian D Perkins
Journal:  Vision Res       Date:  2009-01-21       Impact factor: 1.886

Review 10.  Structure of cone photoreceptors.

Authors:  Debarshi Mustafi; Andreas H Engel; Krzysztof Palczewski
Journal:  Prog Retin Eye Res       Date:  2009-06-06       Impact factor: 21.198
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