Literature DB >> 1793053

The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats.

H Nakajima1, H Takamori, Y Hiyama, W Tsukada.   

Abstract

We have investigated the effects of recombinant rat gamma-interferon (rIFN gamma) on adjuvant-induced arthritis (AA). Lewis rats, inoculated in the left hind-paw with adjuvant (day 0), were given 10(5) U/rat of rIFN gamma daily (days 0 to 20), subcutaneously and intramuscularly on alternate days. rIFN gamma suppressed the secondary phase of swelling of both hind-paw on and after day 18 without influencing the earlier phases, both primary and secondary, of swelling. rIFN gamma also reduced the hind-paw bone lesions, the degree of splenomegaly, and the increase in erythrocyte sedimentation rate and plasma fibrinogen. These results indicate a new aspect of the regulatory role of IFN gamma in chronic inflammation.

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Year:  1991        PMID： 1793053     DOI： 10.1007/bf01993239

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  [Rapid physiological coagulation method in determination of fibrinogen].

Authors:  A CLAUSS
Journal:  Acta Haematol       Date:  1957-04       Impact factor: 2.195

2.  Suppression and augmentation of rat adjuvant arthritis with monoclonal anti-interferon-gamma antibody.

Authors:  I Wiesenberg; P H Van der Meide; H Schellekens; S Alkan
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

3.  Interferons and rheumatoid arthritis: insight into interferon biology?

Authors:  J Browning
Journal:  Immunol Today       Date:  1987

4.  Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis.

Authors:  G W Cannon; R D Emkey; A Denes; S A Cohen; P A Saway; F Wolfe; A M Jaffer; A L Weaver; L Cogen; J Gulinello
Journal:  J Rheumatol       Date:  1990-03       Impact factor: 4.666

5.  Results of a multicenter placebo-controlled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma.

Authors:  E M Lemmel; D Brackertz; M Franke; W Gaus; P W Hartl; K Machalke; H Mielke; H J Obert; H H Peter; J Sieper
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

6.  Interferon gamma in rheumatoid arthritis--a double blind study comparing human recombinant interferon gamma with placebo.

Authors:  E M Veys; H Mielants; G Verbruggen; J P Grosclaude; W Meyer; A Galazka; J Schindler
Journal:  J Rheumatol       Date:  1988-04       Impact factor: 4.666

7.  Heterogeneous effects of IFN-gamma in adjuvant arthritis.

Authors:  C O Jacob; J Holoshitz; P Van der Meide; S Strober; H O McDevitt
Journal:  J Immunol       Date:  1989-03-01       Impact factor: 5.422

8.  Immune interferon: a pleiotropic lymphokine with multiple effects.

Authors:  G Trinchieri; B Perussia
Journal:  Immunol Today       Date:  1985-04
  8 in total
  4 in total

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Review 2.  Regulation of autoimmune inflammation by pro-inflammatory cytokines.

Authors:  Eugene Y Kim; Kamal D Moudgil
Journal:  Immunol Lett       Date:  2008-08-09       Impact factor: 3.685

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4.  The dynamics of articular leukocyte trafficking and the immune response to self heat-shock protein 65 influence arthritis susceptibility.

Authors:  Md Y Mia; Eugene Y Kim; Shailesh R Satpute; Kamal D Moudgil
Journal:  J Clin Immunol       Date:  2008-05-15       Impact factor: 8.317
  4 in total

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