Sufficiently long-term treatment with combined growth hormone and gonadotropin-releasing hormone analog can improve adult height in short children with isolated growth hormone deficiency (GHD) and in non-GHD short children.

GnRHa treatment can decelerate the bone age advancement and delay the epiphyseal closure, and GH can compensate the decreased pubertal height velocity by suppressing sex steroid hormones. It is reasonably concluded from long-term controlled studies that combined GH and GnRHa treatment does effectively increase total pubertal growth and improve adult height in short children with isolated GHD and non-GHD who enter puberty at short stature when the additional GnRHa treatment is continued for more than three years, although there a proper large randomized control trial is necessary to confirm surely the efficacy of combined GH and GnRHa treatment.