BACKGROUND: Threonine is an essential amino acid that is abundantly present in intestinally produced glycoproteins. Animal studies show that intestinal first-pass threonine metabolism is high, particularly during a restricted enteral protein intake. OBJECTIVE: The objective of the study was to quantify intestinal first-pass threonine metabolism in preterm infants during full enteral feeding and during restricted enteral intake. DESIGN: Eight preterm infants (x +/- SD birth weight: 1.1 +/- 0.1 kg; gestational age: 29 +/- 2 wk) were studied during 2 periods. During period A, 40% of total intake was administered enterally and 60% was administered parenterally. Total threonine intake was 58 +/- 6 micromol kg(-1) h(-1). During period B, the infants received full enteral feeding, and the total threonine intake was 63 +/- 6 micromol kg(-1) h(-1). Dual stable-isotope tracer techniques were used to assess splanchnic and whole-body threonine kinetics. RESULTS: The fractional first-pass threonine uptake by the intestine was remarkably high in both periods: 82 +/- 6% during partial enteral feeding and 70 +/- 6% during full enteral feeding. Net threonine retention was not affected by the route of feeding. CONCLUSION: In preterm infants, the splanchnic tissues extract a very large amount of the dietary threonine intake, which indicates a high obligatory visceral need for threonine, presumably for the purposes of synthesis.
BACKGROUND:Threonine is an essential amino acid that is abundantly present in intestinally produced glycoproteins. Animal studies show that intestinal first-pass threonine metabolism is high, particularly during a restricted enteral protein intake. OBJECTIVE: The objective of the study was to quantify intestinal first-pass threonine metabolism in preterm infants during full enteral feeding and during restricted enteral intake. DESIGN: Eight preterm infants (x +/- SD birth weight: 1.1 +/- 0.1 kg; gestational age: 29 +/- 2 wk) were studied during 2 periods. During period A, 40% of total intake was administered enterally and 60% was administered parenterally. Total threonine intake was 58 +/- 6 micromol kg(-1) h(-1). During period B, the infants received full enteral feeding, and the total threonine intake was 63 +/- 6 micromol kg(-1) h(-1). Dual stable-isotope tracer techniques were used to assess splanchnic and whole-body threonine kinetics. RESULTS: The fractional first-pass threonine uptake by the intestine was remarkably high in both periods: 82 +/- 6% during partial enteral feeding and 70 +/- 6% during full enteral feeding. Net threonine retention was not affected by the route of feeding. CONCLUSION: In preterm infants, the splanchnic tissues extract a very large amount of the dietary threonine intake, which indicates a high obligatory visceral need for threonine, presumably for the purposes of synthesis.
Authors: Patrycja Puiman; Barbara Stoll; Lars Mølbak; Adrianus de Bruijn; Henk Schierbeek; Mette Boye; Günther Boehm; Ingrid Renes; Johannes van Goudoever; Douglas Burrin Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-11-08 Impact factor: 4.052
Authors: Mikkel Lykke; Anne-Louise Hother; Christian F Hansen; Henrik Friis; Christian Mølgaard; Kim F Michaelsen; André Briend; Torben Larsen; Per T Sangild; Thomas Thymann Journal: Am J Transl Res Date: 2013-08-15 Impact factor: 4.060
Authors: Subodh J Saggi; Kelly Mercier; Jessica R Gooding; Eli Friedman; Usha Vyas; Natarajan Ranganathan; Pari Ranganathan; Susan McRitchie; Susan Sumner Journal: Int J Probiotics Prebiotics Date: 2017-08-21
Authors: Carlijn T de Betue; Dick A van Waardenburg; Nicolaas E Deutz; Hans M van Eijk; Johannes B van Goudoever; Yvette C Luiking; Luc J Zimmermann; Koen F Joosten Journal: Arch Dis Child Date: 2011-06-14 Impact factor: 3.791
Authors: David Berry; Bärbel Stecher; Arno Schintlmeister; Jochen Reichert; Sandrine Brugiroux; Birgit Wild; Wolfgang Wanek; Andreas Richter; Isabella Rauch; Thomas Decker; Alexander Loy; Michael Wagner Journal: Proc Natl Acad Sci U S A Date: 2013-03-04 Impact factor: 11.205
Authors: Lin Feng; Yan Peng; Pei Wu; Kai Hu; Wei-Dan Jiang; Yang Liu; Jun Jiang; Shu-Hong Li; Xiao-Qiu Zhou Journal: PLoS One Date: 2013-07-26 Impact factor: 3.240