| Literature DB >> 17920402 |
Santiago Munné1, Luca Gianaroli, Ilan Tur-Kaspa, Cristina Magli, Mireia Sandalinas, Jamie Grifo, David Cram, Semra Kahraman, Yury Verlinsky, Joe L Simpson.
Abstract
The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial.Entities:
Mesh：
Year: 2007 PMID： 17920402 DOI： 10.1016/j.fertnstert.2007.08.002
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329