Literature DB >> 1791913

Expression of actin and myosin genes during PC12 cell differentiation.

R C Henke1, O Tolhurst, J W Sentry, P Gunning, P L Jeffrey.   

Abstract

We have measured the accumulation of transcripts for myosin and actin during NGF induced differentiation of PC12 cells. Beta (beta) and gamma (gamma) actin and myosin light chains (MLC) 2 and 3 show different patterns of expression, with transient elevations in gene expression one day after NGF addition. This elevation occurs earlier than that of neurite outgrowth, neurofilament protein (NF68) (16) and Thy-1 glycoprotein gene expression. These results suggest differing mechanisms of control of actin and myosin expression, together with a varying function and relationship between them during NGF-induced neurite differentiation.

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Year:  1991        PMID： 1791913     DOI： 10.1007/bf00965554

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  18 in total

1.  Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells.

Authors:  N M Gough
Journal:  Anal Biochem       Date:  1988-08-15       Impact factor: 3.365

2.  Changes in the organization of the neuritic cytoskeleton during nerve growth factor-activated differentiation of PC12 cells: a serial electron microscopic study of the development and control of neurite shape.

Authors:  J R Jacobs; J K Stevens
Journal:  J Cell Biol       Date:  1986-09       Impact factor: 10.539

3.  Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes.

Authors:  H P Erba; P Gunning; L Kedes
Journal:  Nucleic Acids Res       Date:  1986-07-11       Impact factor: 16.971

4.  Nerve growth factor-induced differentiation of PC12 cells: evaluation of changes in RNA and DNA metabolism.

Authors:  P W Gunning; G E Landreth; P Layer; M Ignatius; E M Shooter
Journal:  J Neurosci       Date:  1981-04       Impact factor: 6.167

5.  Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.

Authors:  D L Hailstones; P W Gunning
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

6.  Isolation and characterization of expressible cDNA clones for mouse Thy-1: a model system for cDNA expression of cell surface proteins.

Authors:  D D Hiraki; D Nomura; T Yokota; K Arai; R L Coffman
Journal:  J Immunol       Date:  1986-06-01       Impact factor: 5.422

7.  Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells.

Authors:  G Dickson; H Prentice; J P Julien; G Ferrari; A Leon; F S Walsh
Journal:  EMBO J       Date:  1986-12-20       Impact factor: 11.598

8.  Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

Authors:  D G Drubin; S C Feinstein; E M Shooter; M W Kirschner
Journal:  J Cell Biol       Date:  1985-11       Impact factor: 10.539

9.  Chick brain actin and myosin. Isolation and characterization.

Authors:  E R Kuczmarski; J L Rosenbaum
Journal:  J Cell Biol       Date:  1979-02       Impact factor: 10.539

10.  Changes in the colchicine susceptibility of microtubules associated with neurite outgrowth: studies with nerve growth factor-responsive PC12 pheochromocytoma cells.

Authors:  M M Black; L A Greene
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539
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  1 in total

1.  Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent on morphological differentiation.

Authors:  R P Weinberger; R C Henke; O Tolhurst; P L Jeffrey; P Gunning
Journal:  J Cell Biol       Date:  1993-01       Impact factor: 10.539
  1 in total

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