Literature DB >> 17918849

Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate.

Krisztina Toth1, Tina L Amyes, Bryant M Wood, Kui Chan, John A Gerlt, John P Richard.   

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Year:  2007        PMID： 17918849      PMCID： PMC2483675          DOI： 10.1021/ja076222f

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  11 in total

1.  Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.

Authors:  N Wu; Y Mo; J Gao; E F Pai
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

2.  Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.

Authors:  B G Miller; A M Hassell; R Wolfenden; M V Milburn; S A Short
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

Review 3.  Enzymatic reactions involving novel mechanisms of carbanion stabilization.

Authors:  Tadhg P Begley; Steven E Ealick
Journal:  Curr Opin Chem Biol       Date:  2004-10       Impact factor: 8.822

4.  Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization.

Authors:  A Warshel; M Strajbl; J Villà; J Florián
Journal:  Biochemistry       Date:  2000-12-05       Impact factor: 3.162

5.  Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts.

Authors:  Tina L Amyes; John P Richard; James J Tait
Journal:  J Am Chem Soc       Date:  2005-11-16       Impact factor: 15.419

6.  A proficient enzyme.

Authors:  A Radzicka; R Wolfenden
Journal:  Science       Date:  1995-01-06       Impact factor: 47.728

Review 7.  Solvent isotope effects of enzyme systems.

Authors:  K B Schowen; R L Schowen
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

Review 8.  The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.

Authors:  T P Begley; T C Appleby; S E Ealick
Journal:  Curr Opin Struct Biol       Date:  2000-12       Impact factor: 6.809

9.  Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects.

Authors:  M A Rishavy; W W Cleland
Journal:  Biochemistry       Date:  2000-04-25       Impact factor: 3.162

10.  Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase.

Authors:  Pernille Harris; Jens-Christian Navarro Poulsen; Kaj Frank Jensen; Sine Larsen
Journal:  J Mol Biol       Date:  2002-05-10       Impact factor: 5.469
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  31 in total

1.  Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.

Authors:  Maria Elena Meza-Avina; Lianhu Wei; Yan Liu; Ewa Poduch; Angelica M Bello; Ram K Mishra; Emil F Pai; Lakshmi P Kotra
Journal:  Bioorg Med Chem       Date:  2010-04-09       Impact factor: 3.641

2.  Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.

Authors:  Tina L Amyes; Shonoi A Ming; Lawrence M Goldman; B McKay Wood; Bijoy J Desai; John A Gerlt; John P Richard
Journal:  Biochemistry       Date:  2012-05-31       Impact factor: 3.162

3.  Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.

Authors:  Krisztina Toth; Tina L Amyes; Bryant M Wood; Kui Chan; John A Gerlt; John P Richard
Journal:  J Am Chem Soc       Date:  2010-05-26       Impact factor: 15.419

4.  Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP.

Authors:  Tina L Amyes; Bryant M Wood; Kui Chan; John A Gerlt; John P Richard
Journal:  J Am Chem Soc       Date:  2008-01-11       Impact factor: 15.419

5.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.

Authors:  Kui K Chan; B McKay Wood; Alexander A Fedorov; Elena V Fedorov; Heidi J Imker; Tina L Amyes; John P Richard; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2009-06-23       Impact factor: 3.162

6.  The use of reaction timecourses to determine the level of minor contaminants in enzyme preparations.

Authors:  Lawrence M Goldman; Tina L Amyes
Journal:  Anal Biochem       Date:  2014-01-03       Impact factor: 3.365

7.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

Authors:  Vanessa Iiams; Bijoy J Desai; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2011-09-06       Impact factor: 3.162

8.  Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.

Authors:  Bogdana Goryanova; Krisztina Spong; Tina L Amyes; John P Richard
Journal:  Biochemistry       Date:  2013-01-11       Impact factor: 3.162

Review 9.  Enzyme (re)design: lessons from natural evolution and computation.

Authors:  John A Gerlt; Patricia C Babbitt
Journal:  Curr Opin Chem Biol       Date:  2009-02-23       Impact factor: 8.822

10.  Phosphate binding energy and catalysis by small and large molecules.

Authors:  Janet R Morrow; Tina L Amyes; John P Richard
Journal:  Acc Chem Res       Date:  2008-02-23       Impact factor: 22.384
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