Literature DB >> 17915881

Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2'-deoxyguanosine oxidation by chromium(V).

Peter G Slade1, Nigel D Priestley, Kent D Sugden.   

Abstract

Oxidation of the DNA lesion 8-oxo-2'-deoxyguanosine by the two electron oxidants N,N'-ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.

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Year:  2007        PMID： 17915881     DOI： 10.1021/ol701667t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.

Authors:  Xin Chen; Aaron M Fleming; James G Muller; Cynthia J Burrows
Journal:  New J Chem       Date:  2013-11-01       Impact factor: 3.591

Review 2.  Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis.

Authors:  A Chiu; X L Shi; W K P Lee; R Hill; T P Wakeman; A Katz; B Xu; N S Dalal; J D Robertson; C Chen; N Chiu; L Donehower
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2010-07       Impact factor: 3.781

3.  Influence of substrate complexity on the diastereoselective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation.

Authors:  Julia N Gremaud; Brooke D Martin; Kent D Sugden
Journal:  Chem Res Toxicol       Date:  2010-02-15       Impact factor: 3.739

4.  Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions.

Authors:  Yu Ye; Barbara H Munk; James G Muller; Alexander Cogbill; Cynthia J Burrows; H Bernhard Schlegel
Journal:  Chem Res Toxicol       Date:  2009-03-16       Impact factor: 3.739

5.  Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.

Authors:  Bradford Brooks; Travis J O'Brien; Susan Ceryak; John Pierce Wise; Sandra S Wise; John Pierce Wise; Edward Defabo; Steven R Patierno
Journal:  Carcinogenesis       Date:  2008-03-10       Impact factor: 4.944

Review 6.  Chromium in drinking water: sources, metabolism, and cancer risks.

Authors:  Anatoly Zhitkovich
Journal:  Chem Res Toxicol       Date:  2011-07-28       Impact factor: 3.739

7.  Mechanism of Resveratrol Dimers Isolated from Grape Inhibiting 1O2 Induced DNA Damage by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2 Analyses.

Authors:  Qingjun Kong; Qingzhi Zeng; Jia Yu; Hongxi Xiao; Jun Lu; Xueyan Ren
Journal:  Biomedicines       Date:  2021-03-08
  7 in total

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