| Literature DB >> 17911019 |
Naoki Teno1, Takahiro Miyake, Takeru Ehara, Osamu Irie, Junichi Sakaki, Osamu Ohmori, Hiroki Gunji, Naoko Matsuura, Keiichi Masuya, Yuko Hitomi, Kazuhiko Nonomura, Miyuki Horiuchi, Keigo Gohda, Atsuko Iwasaki, Ichiro Umemura, Sachiyo Tada, Motohiko Kometani, Genji Iwasaki, Sandra W Cowan-Jacob, Martin Missbach, René Lattmann, Claudia Betschart.
Abstract
Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.Entities:
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Year: 2007 PMID： 17911019 DOI： 10.1016/j.bmcl.2007.09.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823