| Literature DB >> 17910463 |
Tim D Smith1, James B Gerken, Parag V Jog, John D Roberts.
Abstract
The conformational preferences of ethanolamine and its hydrochloride in solution were estimated by comparing experimental NMR vicinal proton-proton coupling constants to semiemprical coupling constants for each staggered rotamer, derived by the Haasnoot-Altona method. Strong gauche preferences are observed for both ethanolamine and its hydrochloride over a wide range of solvent polarities. Concentration was not observed to significantly affect the position of the conformer equilibria.Entities:
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Year: 2007 PMID： 17910463 DOI： 10.1021/ol7020077
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005