Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration.

Literature DB >> 17909623

Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration.

Jing Chen¹, Kip M Connor, Lois E H Smith.

Abstract

Age-related macular degeneration (AMD), the most common cause of blindness in the elderly, is characterized by degeneration of the macula and can lead to loss of fine color vision. Alterations in inflammatory and immune system pathways, which arise from genetic differences, predispose individuals to AMD. Yet the mechanism of disease progression with respect to inflammation is not fully understood. In this issue of the JCI, the study by Combadière and colleagues shows that CX3C chemokine receptor 1-deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17909623 PMCID： PMC1994636 DOI： 10.1172/JCI33513

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

20 in total

1. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Authors:
Journal: Arch Ophthalmol Date: 2001-10

2. Risk factors for age-related macular degeneration: Pooled findings from three continents.

Authors: W Smith; J Assink; R Klein; P Mitchell; C C Klaver; B E Klein; A Hofman; S Jensen; J J Wang; P T de Jong
Journal: Ophthalmology Date: 2001-04 Impact factor: 12.079

3. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease.

Authors: R F Mullins; S R Russell; D H Anderson; G S Hageman
Journal: FASEB J Date: 2000-05 Impact factor: 5.191

Review 4. The role of oxidative stress in the pathogenesis of age-related macular degeneration.

Authors: S Beatty; H Koh; M Phil; D Henson; M Boulton
Journal: Surv Ophthalmol Date: 2000 Sep-Oct Impact factor: 6.048

Review 5. A role for local inflammation in the formation of drusen in the aging eye.

Authors: Don H Anderson; Robert F Mullins; Gregory S Hageman; Lincoln V Johnson
Journal: Am J Ophthalmol Date: 2002-09 Impact factor: 5.258

6. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.

Authors: Jayakrishna Ambati; Akshay Anand; Stefan Fernandez; Eiji Sakurai; Bert C Lynn; William A Kuziel; Barrett J Rollins; Balamurali K Ambati
Journal: Nat Med Date: 2003-10-19 Impact factor: 53.440

7. Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization.

Authors: Diego G Espinosa-Heidmann; Ivan J Suner; Eleut P Hernandez; Dagoberto Monroy; Karl G Csaky; Scott W Cousins
Journal: Invest Ophthalmol Vis Sci Date: 2003-08 Impact factor: 4.799

8. The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.

Authors: Jingsheng Tuo; Brena C Smith; Christine M Bojanowski; Annal D Meleth; Igal Gery; Karl G Csaky; Emily Y Chew; Chi-Chao Chan
Journal: FASEB J Date: 2004-06-18 Impact factor: 5.191

9. Fractalkine mediates natural killer-dependent antitumor responses in vivo.

Authors: Elise Lavergne; Behazine Combadière; Olivia Bonduelle; Mutsunori Iga; Ji-Liang Gao; Maud Maho; Alexandre Boissonnas; Philip M Murphy; Patrice Debré; Christophe Combadière
Journal: Cancer Res Date: 2003-11-01 Impact factor: 12.701

10. The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20.

Authors: John Paul SanGiovanni; Emily Y Chew; Traci E Clemons; Matthew D Davis; Frederick L Ferris; Gary R Gensler; Natalie Kurinij; Anne S Lindblad; Roy C Milton; Johanna M Seddon; Robert D Sperduto
Journal: Arch Ophthalmol Date: 2007-05

9 in total

1. Transcriptional code and disease map for adult retinal cell types.

Authors: Sandra Siegert; Erik Cabuy; Brigitte Gross Scherf; Hubertus Kohler; Satchidananda Panda; Yun-Zheng Le; Hans Jörg Fehling; Dimos Gaidatzis; Michael B Stadler; Botond Roska
Journal: Nat Neurosci Date: 2012-01-22 Impact factor: 24.884

Review 2. Immunopathological aspects of age-related macular degeneration.

Authors: Mrinali Patel; Chi-Chao Chan
Journal: Semin Immunopathol Date: 2008-02-26 Impact factor: 9.623

Review 3. Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.

Authors: Xiaoming Hu; Anthony K F Liou; Rehana K Leak; Mingyue Xu; Chengrui An; Jun Suenaga; Yejie Shi; Yanqin Gao; Ping Zheng; Jun Chen
Journal: Prog Neurobiol Date: 2014-06-09 Impact factor: 11.685