Literature DB >> 17909593

Enhanced weak-signal sensitivity in two-photon microscopy by adaptive illumination.

Kengyeh K Chu1, Daryl Lim, Jerome Mertz.   

Abstract

We describe a technique to enhance both the weak-signal relative sensitivity and the dynamic range of a laser scanning optical microscope. The technique is based on maintaining a fixed detection power by fast feedback control of the illumination power, thereby transferring high measurement resolution to weak signals while virtually eliminating the possibility of image saturation. We analyze and demonstrate the benefits of adaptive illumination in two-photon fluorescence microscopy.

Mesh：

Year:  2007        PMID： 17909593     DOI： 10.1364/ol.32.002846

Source DB:  PubMed          Journal:  Opt Lett        ISSN： 0146-9592            Impact factor:   3.776


  10 in total

Review 1.  Optical sectioning microscopy with planar or structured illumination.

Authors:  Jerome Mertz
Journal:  Nat Methods       Date:  2011-09-29       Impact factor: 28.547

2.  Fast fluorescence microscopy for imaging the dynamics of embryonic development.

Authors:  Julien Vermot; Scott E Fraser; Michael Liebling
Journal:  HFSP J       Date:  2008-05-13

3.  Adaptive illumination reduces photobleaching in structured illumination microscopy.

Authors:  Nadya Chakrova; Alicia Soler Canton; Christophe Danelon; Sjoerd Stallinga; Bernd Rieger
Journal:  Biomed Opt Express       Date:  2016-09-23       Impact factor: 3.732

4.  High dynamic range fluorescence imaging.

Authors:  Claudio Vinegoni; Paolo Fumene Feruglio; Ralph Weissleder
Journal:  IEEE J Sel Top Quantum Electron       Date:  2018-11-19       Impact factor: 4.544

5.  Event-driven acquisition for content-enriched microscopy.

Authors:  Dora Mahecic; Willi L Stepp; Chen Zhang; Juliette Griffié; Martin Weigert; Suliana Manley
Journal:  Nat Methods       Date:  2022-09-08       Impact factor: 47.990

6.  Precisely calibrated and spatially informed illumination for conventional fluorescence and improved PALM imaging applications.

Authors:  Angel Mancebo; Luke DeMars; Christopher T Ertsgaard; Elias M Puchner
Journal:  Methods Appl Fluoresc       Date:  2020-02-19       Impact factor: 3.009

7.  Practical implementation of log-scale active illumination microscopy.

Authors:  Kengyeh K Chu; Daryl Lim; Jerome Mertz
Journal:  Biomed Opt Express       Date:  2010-07-16       Impact factor: 3.732

8.  A rapid denoised contrast enhancement method digitally mimicking an adaptive illumination in submicron-resolution neuronal imaging.

Authors:  Bhaskar Jyoti Borah; Chi-Kuang Sun
Journal:  iScience       Date:  2022-01-15

9.  Real-time high dynamic range laser scanning microscopy.

Authors:  C Vinegoni; C Leon Swisher; P Fumene Feruglio; R J Giedt; D L Rousso; S Stapleton; R Weissleder
Journal:  Nat Commun       Date:  2016-04-01       Impact factor: 14.919

10.  Neuronal imaging with ultrahigh dynamic range multiphoton microscopy.

Authors:  Ruohui Yang; Timothy D Weber; Ellen D Witkowski; Ian G Davison; Jerome Mertz
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
  10 in total

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