OBJECTIVES: We examined the association of potential risk factors with the incidence of biliary tract cancer in a large-scale population-based cohort study. Particular focus was placed on a history of cholelithiasis, body mass index (BMI), and their effect modification, and whether risk differs by cancer subsite, namely by gallbladder cancer and extrahepatic bile duct cancer. DESIGN: We investigated 101,868 middle-aged and older Japanese subjects (48,681 men and 53,187 women) during 1,200,386 person-years of follow-up. RESULTS: A total of 235 cases of biliary tract cancer (93 gallbladder cancer and 142 extrahepatic bile duct cancer) were newly diagnosed. Cholelithiasis was associated with an increased risk of biliary tract cancer [HR, 2.53; 95% CI, 1.56-4.12]. This association was similarly observed for both gallbladder [HR, 3.01; 95% CI, 1.56-6.19] and extrahepatic bile duct cancer [HR, 2.12; 95% CI, 1.08-4.18]. Body mass index was associated with an increased risk of extrahepatic bile duct cancer (P for trend = 0.03) and this effect was not modified by a history of cholelithiasis. CONCLUSIONS: Cholelithiasis was confirmed to be associated with the risk of biliary tract cancer, both gallbladder and extrahepatic bile duct cancer. Obesity may increase the risk of extrahepatic bile duct cancer only, independent of cholelithiasis.
OBJECTIVES: We examined the association of potential risk factors with the incidence of biliary tract cancer in a large-scale population-based cohort study. Particular focus was placed on a history of cholelithiasis, body mass index (BMI), and their effect modification, and whether risk differs by cancer subsite, namely by gallbladder cancer and extrahepatic bile duct cancer. DESIGN: We investigated 101,868 middle-aged and older Japanese subjects (48,681 men and 53,187 women) during 1,200,386 person-years of follow-up. RESULTS: A total of 235 cases of biliary tract cancer (93 gallbladder cancer and 142 extrahepatic bile duct cancer) were newly diagnosed. Cholelithiasis was associated with an increased risk of biliary tract cancer [HR, 2.53; 95% CI, 1.56-4.12]. This association was similarly observed for both gallbladder [HR, 3.01; 95% CI, 1.56-6.19] and extrahepatic bile duct cancer [HR, 2.12; 95% CI, 1.08-4.18]. Body mass index was associated with an increased risk of extrahepatic bile duct cancer (P for trend = 0.03) and this effect was not modified by a history of cholelithiasis. CONCLUSIONS:Cholelithiasis was confirmed to be associated with the risk of biliary tract cancer, both gallbladder and extrahepatic bile duct cancer. Obesity may increase the risk of extrahepatic bile duct cancer only, independent of cholelithiasis.
Authors: Peter T Campbell; Christina C Newton; Cari M Kitahara; Alpa V Patel; Patricia Hartge; Jill Koshiol; Katherine A McGlynn; Hans-Olov Adami; Amy Berrington de González; Laura E Beane Freeman; Leslie Bernstein; Julie E Buring; Neal D Freedman; Yu-Tang Gao; Graham G Giles; Marc J Gunter; Mazda Jenab; Linda M Liao; Roger L Milne; Kim Robien; Dale P Sandler; Catherine Schairer; Howard D Sesso; Xiao-Ou Shu; Elisabete Weiderpass; Alicja Wolk; Yong-Bing Xiang; Anne Zeleniuch-Jacquotte; Wei Zheng; Susan M Gapstur Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-03-17 Impact factor: 4.254
Authors: Sarah S Jackson; Alison L Van Dyke; Bin Zhu; Ruth M Pfeiffer; Jessica L Petrick; Hans-Olov Adami; Demetrius Albanes; Gabriella Andreotti; Laura E Beane Freeman; Amy Berrington de González; Julie E Buring; Andrew T Chan; Yu Chen; Gary E Fraser; Neal D Freedman; Yu-Tang Gao; Susan M Gapstur; J Michael Gaziano; Graham G Giles; Eric J Grant; Francine Grodstein; Patricia Hartge; Mazda Jenab; Cari M Kitahara; Synnove F Knutsen; Woon-Puay Koh; Susanna C Larsson; I-Min Lee; Linda M Liao; Juhua Luo; Emma E McGee; Roger L Milne; Kristine R Monroe; Marian L Neuhouser; Katie M O'Brien; Ulrike Peters; Jenny N Poynter; Mark P Purdue; Kim Robien; Dale P Sandler; Norie Sawada; Catherine Schairer; Howard D Sesso; Tracey G Simon; Rashmi Sinha; Rachael Z Stolzenberg-Solomon; Shoichiro Tsugane; Renwei Wang; Elisabete Weiderpass; Stephanie J Weinstein; Emily White; Alicja Wolk; Jian-Min Yuan; Anne Zeleniuch-Jacquotte; Xuehong Zhang; Katherine A McGlynn; Peter T Campbell; Jill Koshiol Journal: Cancer Res Date: 2019-05-21 Impact factor: 12.701
Authors: Jill Koshiol; Vanessa Van De Wyngard; Emma E McGee; Paz Cook; Ruth M Pfeiffer; Noldy Mardones; Karie Medina; Vanessa Olivo; Karen Pettit; Sarah S Jackson; Fabio Paredes; Raúl Sanchez; Andrea Huidobro; Miguel Villaseca; Enrique Bellolio; Hector Losada; Juan Carlos Roa; Allan Hildesheim; Juan Carlos Araya; Catterina Ferreccio Journal: Am J Epidemiol Date: 2021-02-01 Impact factor: 4.897
Authors: F M Shebl; G Andreotti; T E Meyer; Y-T Gao; A Rashid; K Yu; M-C Shen; B-S Wang; T-Q Han; B-H Zhang; F Z Stanczyk; A W Hsing Journal: Br J Cancer Date: 2011-09-13 Impact factor: 7.640