| Literature DB >> 17906623 |
Nicolette H C Salmon Hillbertz1, Magnus Isaksson, Elinor K Karlsson, Eva Hellmén, Gerli Rosengren Pielberg, Peter Savolainen, Claire M Wade, Henrik von Euler, Ulla Gustafson, Ake Hedhammar, Mats Nilsson, Kerstin Lindblad-Toh, Leif Andersson, Göran Andersson.
Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.Entities:
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Year: 2007 PMID： 17906623 DOI： 10.1038/ng.2007.4
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330