Literature DB >> 17904699

Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice.

Eryu Wang1, Olga Petrakova, A Paige Adams, Patricia V Aguilar, Wenli Kang, Slobodan Paessler, Sara M Volk, Ilya Frolov, Scott C Weaver.   

Abstract

We developed chimeric Sindbis (SINV)/eastern equine encephalitis (EEEV) viruses and investigated their potential for use as live virus vaccines against EEEV. One vaccine candidate contained structural protein genes from a typical North American EEEV strain, while the other had structural proteins from a naturally attenuated Brazilian isolate. Both chimeric viruses replicated efficiently in mammalian and mosquito cell cultures and were highly attenuated in mice. Vaccinated mice did not develop detectable disease or viremia, but developed high titers of neutralizing antibodies. Upon challenge with EEEV, mice vaccinated with >10(4) PFU of the chimeric viruses were completely protected from disease. These findings support the potential use of these SIN/EEEV chimeras as safe and effective vaccines.

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Year:  2007        PMID： 17904699      PMCID： PMC2094013          DOI： 10.1016/j.vaccine.2007.07.061

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  26 in total

1.  Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218.

Authors:  R Edelman; C O Tacket; S S Wasserman; S A Bodison; J G Perry; J A Mangiafico
Journal:  Am J Trop Med Hyg       Date:  2000-06       Impact factor: 2.345

2.  Genetic and antigenic diversity among eastern equine encephalitis viruses from North, Central, and South America.

Authors:  A C Brault; A M Powers; C L Chavez; R N Lopez; M F Cachón; L F Gutierrez; W Kang; R B Tesh; R E Shope; S C Weaver
Journal:  Am J Trop Med Hyg       Date:  1999-10       Impact factor: 2.345

3.  Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.

Authors:  Slobodan Paessler; Haolin Ni; Olga Petrakova; Rafik Z Fayzulin; Nadezhda Yun; Michael Anishchenko; Scott C Weaver; Ilya Frolov
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

4.  Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions.

Authors:  R J Kuhn; D E Griffin; K E Owen; H G Niesters; J H Strauss
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

5.  Early events in the pathogenesis of eastern equine encephalitis virus in mice.

Authors:  Peter Vogel; Wayne M Kell; David L Fritz; Michael D Parker; Randal J Schoepp
Journal:  Am J Pathol       Date:  2005-01       Impact factor: 4.307

6.  Endemic eastern equine encephalitis in the Amazon region of Peru.

Authors:  Patricia V Aguilar; Rebecca M Robich; Michael J Turell; Monica L O'Guinn; Terry A Klein; Alfredo Huaman; Carolina Guevara; Zonia Rios; Robert B Tesh; Douglas M Watts; James Olson; Scott C Weaver
Journal:  Am J Trop Med Hyg       Date:  2007-02       Impact factor: 2.345

7.  Response to and efficacy of vaccination against eastern equine encephalomyelitis virus in emus.

Authors:  L A Tengelsen; R A Bowen; M A Royals; G L Campbell; N Komar; R B Craven
Journal:  J Am Vet Med Assoc       Date:  2001-05-01       Impact factor: 1.936

8.  Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.

Authors:  Patricia V Aguilar; Slobodan Paessler; Anne-Sophie Carrara; Samuel Baron; Joyce Poast; Eryu Wang; Abelardo C Moncayo; Michael Anishchenko; Douglas Watts; Robert B Tesh; Scott C Weaver
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

9.  Venezuelan equine encephalitis virus, southern Mexico.

Authors:  José G Estrada-Franco; Roberto Navarro-Lopez; Jerome E Freier; Dionicio Cordova; Tamara Clements; Abelardo Moncayo; Wenli Kang; Carlos Gomez-Hernandez; Gabriela Rodriguez-Dominguez; George V Ludwig; Scott C Weaver
Journal:  Emerg Infect Dis       Date:  2004-12       Impact factor: 6.883

10.  Protection of pigs by vaccination of pregnant sows against eastern equine encephalomyelitis virus.

Authors:  F Elvinger; C A Baldwin; A D Liggett; K N Tang; C R Dove
Journal:  Vet Microbiol       Date:  1996-08       Impact factor: 3.293
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  42 in total

1.  Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential.

Authors:  Michael Zasloff; A Paige Adams; Bernard Beckerman; Ann Campbell; Ziying Han; Erik Luijten; Isaura Meza; Justin Julander; Abhijit Mishra; Wei Qu; John M Taylor; Scott C Weaver; Gerard C L Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

2.  New PARP gene with an anti-alphavirus function.

Authors:  Svetlana Atasheva; Maryna Akhrymuk; Elena I Frolova; Ilya Frolov
Journal:  J Virol       Date:  2012-05-23       Impact factor: 5.103

Review 3.  Principles of antidote pharmacology: an update on prophylaxis, post-exposure treatment recommendations and research initiatives for biological agents.

Authors:  S Ramasamy; C Q Liu; H Tran; A Gubala; P Gauci; J McAllister; T Vo
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

4.  Stability of RNA virus attenuation approaches.

Authors:  Joan L Kenney; Sara M Volk; Jyotsna Pandya; Eryu Wang; Xiaodong Liang; Scott C Weaver
Journal:  Vaccine       Date:  2011-02-01       Impact factor: 3.641

5.  Use of sindbis/eastern equine encephalitis chimeric viruses in plaque reduction neutralization tests for arboviral disease diagnostics.

Authors:  B W Johnson; O Kosoy; E Wang; M Delorey; B Russell; R A Bowen; S C Weaver
Journal:  Clin Vaccine Immunol       Date:  2011-07-13

6.  Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses.

Authors:  Weiping Peng; Daniel C Peltier; Martha J Larsen; Paul D Kirchhoff; Scott D Larsen; Richard R Neubig; David J Miller
Journal:  J Infect Dis       Date:  2009-04-01       Impact factor: 5.226

Review 7.  Encephalitic alphaviruses.

Authors:  Michele A Zacks; Slobodan Paessler
Journal:  Vet Microbiol       Date:  2009-08-28       Impact factor: 3.293

8.  A multisystem approach for development and evaluation of inactivated vaccines for Venezuelan equine encephalitis virus (VEEV).

Authors:  Donald L Fine; Erin Jenkins; Shannon S Martin; Pamela Glass; Michael D Parker; Brad Grimm
Journal:  J Virol Methods       Date:  2009-11-10       Impact factor: 2.014

9.  Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.

Authors:  Svetlana Atasheva; Dal Young Kim; Maryna Akhrymuk; David G Morgan; Elena I Frolova; Ilya Frolov
Journal:  J Virol       Date:  2012-12-05       Impact factor: 5.103

10.  Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.

Authors:  Svetlana Atasheva; Eryu Wang; A Paige Adams; Kenneth S Plante; Sai Ni; Katherine Taylor; Mary E Miller; Ilya Frolov; Scott C Weaver
Journal:  Vaccine       Date:  2009-05-27       Impact factor: 3.641
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