Literature DB >> 21288800

Stability of RNA virus attenuation approaches.

Joan L Kenney1, Sara M Volk, Jyotsna Pandya, Eryu Wang, Xiaodong Liang, Scott C Weaver.   

Abstract

The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent attenuation approach exemplified by TC-83; a rationally designed, targeted-mutation approach represented by V3526; and a chimeric vaccine, SIN/TC/ZPC. Our findings suggest that the chimeric strain combines the initial attenuation of TC-83 with the greater phenotypic stability of V3526, highlighting the importance of the both initial attenuation and stability for live-attenuated vaccines.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21288800      PMCID： PMC3060670          DOI： 10.1016/j.vaccine.2011.01.055

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  39 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

2.  USE OF AN ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN.

Authors:  R W MCKINNEY; T O BERGE; W D SAWYER; W D TIGERTT; D CROZIER
Journal:  Am J Trop Med Hyg       Date:  1963-07       Impact factor: 2.345

Review 3.  Vaccine-derived polioviruses and the endgame strategy for global polio eradication.

Authors:  Olen M Kew; Roland W Sutter; Esther M de Gourville; Walter R Dowdle; Mark A Pallansch
Journal:  Annu Rev Microbiol       Date:  2005       Impact factor: 15.500

Review 4.  RNA virus mutations and fitness for survival.

Authors:  E Domingo; J J Holland
Journal:  Annu Rev Microbiol       Date:  1997       Impact factor: 15.500

5.  Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.

Authors:  Marco Vignuzzi; Jeffrey K Stone; Jamie J Arnold; Craig E Cameron; Raul Andino
Journal:  Nature       Date:  2005-12-04       Impact factor: 49.962

6.  Long-term duration of detectable neutralizing antibodies after administration of live-attenuated VEE vaccine and following booster vaccination with inactivated VEE vaccine.

Authors:  P R Pittman; R S Makuch; J A Mangiafico; T L Cannon; P H Gibbs; C J Peters
Journal:  Vaccine       Date:  1996-03       Impact factor: 3.641

Review 7.  Smallpox vaccine: the good, the bad, and the ugly.

Authors:  Edward A Belongia; Allison L Naleway
Journal:  Clin Med Res       Date:  2003-04

8.  Packaging signals in alphaviruses.

Authors:  E Frolova; I Frolov; S Schlesinger
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

Review 9.  Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradication.

Authors:  Philip Minor
Journal:  Vaccine       Date:  2009-03-03       Impact factor: 3.641

10.  Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1.

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Journal:  Virology       Date:  1995-09-10       Impact factor: 3.616
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  16 in total

Review 1.  DNA-launched live-attenuated vaccines for biodefense applications.

Authors:  Peter Pushko; Igor S Lukashevich; Scott C Weaver; Irina Tretyakova
Journal:  Expert Rev Vaccines       Date:  2016-04-25       Impact factor: 5.217

2.  Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella.

Authors:  Patricia V Aguilar; Jose G Estrada-Franco; Roberto Navarro-Lopez; Cristina Ferro; Andrew D Haddow; Scott C Weaver
Journal:  Future Virol       Date:  2011       Impact factor: 1.831

3.  Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.

Authors:  Rodion Gorchakov; Eryu Wang; Grace Leal; Naomi L Forrester; Kenneth Plante; Shannan L Rossi; Charalambos D Partidos; A Paige Adams; Robert L Seymour; James Weger; Erin M Borland; Michael B Sherman; Ann M Powers; Jorge E Osorio; Scott C Weaver
Journal:  J Virol       Date:  2012-03-28       Impact factor: 5.103

4.  The double-edged sword: How evolution can make or break a live-attenuated virus vaccine.

Authors:  Kathryn A Hanley
Journal:  Evolution (N Y)       Date:  2011-12

5.  A vaccine candidate for eastern equine encephalitis virus based on IRES-mediated attenuation.

Authors:  Jyotsna Pandya; Rodion Gorchakov; Eryu Wang; Grace Leal; Scott C Weaver
Journal:  Vaccine       Date:  2012-01-02       Impact factor: 3.641

6.  Attenuation of porcine reproductive and respiratory syndrome virus by molecular breeding of virus envelope genes from genetically divergent strains.

Authors:  Yan-Yan Ni; Tanja Opriessnig; Lei Zhou; Dianjun Cao; Yao-Wei Huang; Patrick G Halbur; Xiang-Jin Meng
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

7.  Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine.

Authors:  Irina Tretyakova; Igor S Lukashevich; Pamela Glass; Eryu Wang; Scott Weaver; Peter Pushko
Journal:  Vaccine       Date:  2012-12-31       Impact factor: 3.641

8.  IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice.

Authors:  Shannan L Rossi; Mathilde Guerbois; Rodion Gorchakov; Kenneth S Plante; Naomi L Forrester; Scott C Weaver
Journal:  Virology       Date:  2013-01-22       Impact factor: 3.616

9.  Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism.

Authors:  Kenneth Plante; Eryu Wang; Charalambos D Partidos; James Weger; Rodion Gorchakov; Konstantin Tsetsarkin; Erin M Borland; Ann M Powers; Robert Seymour; Dan T Stinchcomb; Jorge E Osorio; Ilya Frolov; Scott C Weaver
Journal:  PLoS Pathog       Date:  2011-07-28       Impact factor: 6.823

10.  IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.

Authors:  Mathilde Guerbois; Eugenia Volkova; Naomi L Forrester; Shannan L Rossi; Ilya Frolov; Scott C Weaver
Journal:  PLoS Negl Trop Dis       Date:  2013-05-09
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