Literature DB >> 17899320

Molecular interactions in the insulin-like growth factor (IGF) axis: a surface plasmon resonance (SPR) based biosensor study.

James Beattie1, Kirsten Phillips, John H Shand, Malgorzata Szymanowska, David J Flint, Gordon J Allan.   

Abstract

This review describes a comprehensive analysis of a surface plasmon resonance (SPR)-based biosensor study of molecular interactions in the insulin-like growth factor (IGF) molecular axis. In this study, we focus on the interaction between the polypeptide growth factors IGF-I and IGF-II with six soluble IGF binding proteins (IGFBP 1-6), which occur naturally in various biological fluids. We have describe the conditions required for the accurate determination of kinetic rate constants for these interactions and highlight the experimental and theoretical pitfalls, which may be encountered in the early stages of such a study. We focus on IGFBP-5 and describe a site-directed mutagenesis study, which examines the contribution of various residues in the protein to high affinity interaction with IGF-I and -II. We analyse the interaction of IGFBP-5 (and IGFBP-3) with heparin and other biomolecules and describe experiments, which were designed to monitor multi-protein complex formation in this molecular axis.

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Year:  2007        PMID： 17899320     DOI： 10.1007/s11010-007-9601-8

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  55 in total

1.  Insulin-like growth factor (IGF)-binding protein-5-(201-218) region regulates hydroxyapatite and IGF-I binding.

Authors:  P G Campbell; D L Andress
Journal:  Am J Physiol       Date:  1997-11

2.  Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin.

Authors:  Alice M Sorrell; John H Shand; Elizabeth Tonner; Matteo Gamberoni; Pier A Accorsi; James Beattie; Gordon J Allan; David J Flint
Journal:  J Biol Chem       Date:  2006-02-27       Impact factor: 5.157

3.  Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity.

Authors:  Rikke Søe; Michael T Overgaard; Anni R Thomsen; Lisbeth S Laursen; Inger M Olsen; Lars Sottrup-Jensen; Jesper Haaning; Linda C Giudice; Cheryl A Conover; Claus Oxvig
Journal:  Eur J Biochem       Date:  2002-04

4.  Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.

Authors:  M S Wong; C C Fong; M Yang
Journal:  Biochim Biophys Acta       Date:  1999-07-13

5.  Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor.

Authors:  Peter Vorwerk; Bianka Hohmann; Youngman Oh; Ron G Rosenfeld; Ronald M Shymko
Journal:  Endocrinology       Date:  2002-05       Impact factor: 4.736

6.  Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3.

Authors:  A Heding; R Gill; Y Ogawa; P De Meyts; R M Shymko
Journal:  J Biol Chem       Date:  1996-06-14       Impact factor: 5.157

7.  Synthesis and characterization of biotinylated forms of insulin-like growth factor-1: topographical evaluation of the IGF-1/IGFBP-2 AND IGFBP-3 interface.

Authors:  Stephanie A Robinson; Steven A Rosenzweig
Journal:  Biochemistry       Date:  2004-09-14       Impact factor: 3.162

8.  Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta 1 release IGF-binding protein-3 from human fibroblasts by different mechanisms.

Authors:  J L Martin; M Ballesteros; R C Baxter
Journal:  Endocrinology       Date:  1992-10       Impact factor: 4.736

9.  Human insulin-like growth factor binding protein-6 is O-glycosylated.

Authors:  L A Bach; N R Thotakura; M M Rechler
Journal:  Biochem Biophys Res Commun       Date:  1992-07-15       Impact factor: 3.575

10.  Effects of full-length and truncated insulin-like growth factor-I on nitrogen balance and muscle protein metabolism in nitrogen-restricted rats.

Authors:  F M Tomas; S E Knowles; P C Owens; L C Read; C S Chandler; S E Gargosky; F J Ballard
Journal:  J Endocrinol       Date:  1991-01       Impact factor: 4.286
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  6 in total

Review 1.  The role of the insulin‑like growth factor (IGF) axis in osteogenic and odontogenic differentiation.

Authors:  H Al-Kharobi; R El-Gendy; D A Devine; J Beattie
Journal:  Cell Mol Life Sci       Date:  2014-04       Impact factor: 9.261

2.  Modification of the zonal elution method for detection of transient protein-protein interactions involving ligand exchange.

Authors:  Virginie Sjoelund; Igor A Kaltashov
Journal:  Anal Chem       Date:  2012-04-25       Impact factor: 6.986

3.  Binding between insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 is not influenced by glucose or 2-deoxy-D-glucose.

Authors:  Matei Mireuta; Mark A Hancock; Michael Pollak
Journal:  J Biol Chem       Date:  2011-03-09       Impact factor: 5.157

Review 4.  IGF binding proteins in cancer: mechanistic and clinical insights.

Authors:  Robert C Baxter
Journal:  Nat Rev Cancer       Date:  2014-04-10       Impact factor: 60.716

Review 5.  Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment.

Authors:  Kunal Amratlal Lodhia; Piyawan Tienchaiananda; Paul Haluska
Journal:  Front Oncol       Date:  2015-07-08       Impact factor: 6.244

Review 6.  Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer.

Authors:  Kamila A Marzec; Robert C Baxter; Janet L Martin
Journal:  Biomed Res Int       Date:  2015-06-28       Impact factor: 3.411
  6 in total

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