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Literature DB >> 17897944

Structure and mechanism of lysine-specific demethylase enzymes.

Abstract

The discovery of histone-demethylating enzymes has revealed yet another reversible histone modification mark. In this review, we describe the structural and chemical insights that we have now derived underlying the activity of these enzymes. The recent co-crystal structures of LSD1 bound to a proparylamine-derivatized histone H3 peptide and JHDM structures bound to two different methylated histone H3 peptides illustrate the steric requirements and structural basis for substrate specificity.

Entities: Chemical Gene

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Year: 2007 PMID： 17897944 DOI： 10.1074/jbc.R700027200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

47 in total

1. Histone demethylase LSD1 is a folate-binding protein.

Authors: Zigmund Luka; Frank Moss; Lioudmila V Loukachevitch; Darryl J Bornhop; Conrad Wagner
Journal: Biochemistry Date: 2011-05-05 Impact factor: 3.162

2. Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.

Authors: Sheema Fnu; Elizabeth A Williamson; Leyma P De Haro; Mark Brenneman; Justin Wray; Montaser Shaheen; Krishnan Radhakrishnan; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
Journal: Proc Natl Acad Sci U S A Date: 2010-12-27 Impact factor: 11.205

3. Histone methylation has dynamics distinct from those of histone acetylation in cell cycle reentry from quiescence.

Authors: Philipp Mews; Barry M Zee; Sherry Liu; Greg Donahue; Benjamin A Garcia; Shelley L Berger
Journal: Mol Cell Biol Date: 2014-08-25 Impact factor: 4.272

Review 4. Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease.

Authors: Siming Shen; Patrizia Casaccia-Bonnefil
Journal: J Mol Neurosci Date: 2008-05 Impact factor: 3.444

Structure and mechanism of lysine-specific demethylase enzymes.

1. Histone demethylase LSD1 is a folate-binding protein.

2. Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.

3. Histone methylation has dynamics distinct from those of histone acetylation in cell cycle reentry from quiescence.

Review 4. Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease.

Review 5. The role of histone demethylases in cancer therapy.

Review 6. Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.

Review 7. Developmental roles of the histone lysine demethylases.

8. Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.

9. Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms.

10. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption.