| Literature DB >> 17896821 |
Qian Li1, Rachel M Ndonye, Petr A Illarionov, Karl O A Yu, Elliot S Jerud, Kristine Diaz, Gabriel Bricard, Steven A Porcelli, Gurdyal S Besra, Young-Tae Chang, Amy R Howell.
Abstract
Two 60+-membered libraries of alpha-galactosylceramides have been prepared by reactions between activated ester resins and two core, fully deprotected galactosylated sphingoid bases. The libraries were evaluated for their ability to stimulate CD1d-restricted NKT cells, using in vitro stimulation of a murine NKT cell hybridoma line and for their ability to induce the expansion of NKT cells from peripheral blood mononuclear cells (PBMC) of a normal human subject. Our results showed that many compounds constructed on a C18-phytosphingosine base had significant stimulatory activity in both assays. Because no product purification was required, this approach is particularly attractive as a method for rapid synthesis of large libraries of potential immunomodulatory glycosylceramides.Entities:
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Year: 2007 PMID： 17896821 DOI： 10.1021/cc070057i
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766