PURPOSE: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. MATERIALS AND METHODS: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. RESULTS: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 +/- 0.5, 8.8 +/- 1.8, and 10.9 +/- 2.7 mM, respectively, while in the medulla they were 2.6 +/- 0.5, 9.1 +/- 1.7, and 10.8 +/- 0.9 mM. CONCLUSION: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla. (c) 2007 Wiley-Liss, Inc.
PURPOSE: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. MATERIALS AND METHODS: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. RESULTS: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 +/- 0.5, 8.8 +/- 1.8, and 10.9 +/- 2.7 mM, respectively, while in the medulla they were 2.6 +/- 0.5, 9.1 +/- 1.7, and 10.8 +/- 0.9 mM. CONCLUSION: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla. (c) 2007 Wiley-Liss, Inc.
Authors: Khaled Abdel-Aziz; Torben Schneider; Bhavana S Solanky; Marios C Yiannakas; Dan R Altmann; Claudia A M Wheeler-Kingshott; Amy L Peters; Brian L Day; Alan J Thompson; Olga Ciccarelli Journal: Brain Date: 2015-04-10 Impact factor: 13.501
Authors: P W Stroman; C Wheeler-Kingshott; M Bacon; J M Schwab; R Bosma; J Brooks; D Cadotte; T Carlstedt; O Ciccarelli; J Cohen-Adad; A Curt; N Evangelou; M G Fehlings; M Filippi; B J Kelley; S Kollias; A Mackay; C A Porro; S Smith; S M Strittmatter; P Summers; I Tracey Journal: Neuroimage Date: 2013-05-14 Impact factor: 6.556
Authors: A F Marliani; V Clementi; L Albini Riccioli; R Agati; M Carpenzano; F Salvi; M Leonardi Journal: AJNR Am J Neuroradiol Date: 2009-09-03 Impact factor: 3.825