Literature DB >> 17894449

Wheat germ agglutinin-modified trifunctional nanospheres for cell recognition.

Hai-Yan Xie1, Min Xie, Zhi-Ling Zhang, Yan-Min Long, Xin Liu, Ming-Liang Tang, Dai-Wen Pang, Zheng Tan, Calum Dickinson, Wuzong Zhou.   

Abstract

A simple and convenient strategy has been put forward to fabricate smart fluorescent magnetic wheat germ agglutinin-modified trifunctional nanospheres (WGA-TFNS) for recognition of human prostate carcinoma DU-145 cells which are surface-expressed with sialic acid and N-acetylglucosamine. These TFNS can be easily manipulated, tracked, and conveniently used to capture and separate target cells. The presence of wheat germ agglutinin on the surface of WGA-TFNS was confirmed by FTIR, biorecognition of carboxymethyl chitin-modified quantum dots (CM-CT-QDs), and bacterium Staphylococcus aureus. The success in recognizing DU-145 cells by the WGA-TFNS indicates that WGA-TFNS could be applicable.

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Year:  2007        PMID： 17894449     DOI： 10.1021/bc060387g

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


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