Literature DB >> 17893366

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.

Erika J Mancini1, Rene Assenberg, Anil Verma, Thomas S Walter, Roman Tuma, Jonathan M Grimes, Raymond J Owens, David I Stuart.   

Abstract

Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus endemic to Australia, is closely related to Japanese encephalitis virus and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains, whose activity is central to flavivirus replication and is therefore a possible target for anti-flaviviral compounds. Cloning, purification, and crystal structure determination to 1.9 Angstrom resolution of the NS3 helicase of MVEV and characterization of its enzymatic activity is reported. Comparison with the structures of helicases from related viruses supports a possible mechanism of ATP hydrolysis-driven strand separation.

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Year:  2007        PMID： 17893366      PMCID： PMC2204129          DOI： 10.1110/ps.072843107

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  27 in total

1.  Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.

Authors:  A E Matusan; M J Pryor; A D Davidson; P J Wright
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

2.  Automated protein model building combined with iterative structure refinement.

Authors:  A Perrakis; R Morris; V S Lamzin
Journal:  Nat Struct Biol       Date:  1999-05

3.  CASTp: Computed Atlas of Surface Topography of proteins.

Authors:  T Andrew Binkowski; Shapor Naghibzadeh; Jie Liang
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

4.  3DCoffee: combining protein sequences and structures within multiple sequence alignments.

Authors:  Orla O'Sullivan; Karsten Suhre; Chantal Abergel; Desmond G Higgins; Cédric Notredame
Journal:  J Mol Biol       Date:  2004-07-02       Impact factor: 5.469

5.  The CCP4 suite: programs for protein crystallography.

Authors: 
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1994-09-01

6.  Coot: model-building tools for molecular graphics.

Authors:  Paul Emsley; Kevin Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-11-26

7.  Use of TLS parameters to model anisotropic displacements in macromolecular refinement.

Authors:  M D Winn; M N Isupov; G N Murshudov
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2001-01

8.  Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.

Authors:  Peter Borowski; Melanie Lang; Annemarie Haag; Herbert Schmitz; Joonho Choe; Huan-Ming Chen; Ramachandra S Hosmane
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

9.  CaspR: a web server for automated molecular replacement using homology modelling.

Authors:  Jean-Baptiste Claude; Karsten Suhre; Cédric Notredame; Jean-Michel Claverie; Chantal Abergel
Journal:  Nucleic Acids Res       Date:  2004-07-01       Impact factor: 16.971

10.  Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.

Authors:  Ning Zhang; Huan-Ming Chen; Verena Koch; Herbert Schmitz; Ching-Len Liao; Maria Bretner; Vishweshwar S Bhadti; Ali I Fattom; Robert B Naso; Ramachandra S Hosmane; Peter Borowski
Journal:  J Med Chem       Date:  2003-09-11       Impact factor: 7.446
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  12 in total

1.  Semi-automated microseeding of nanolitre crystallization experiments.

Authors:  Thomas S Walter; Erika J Mancini; Jan Kadlec; Stephen C Graham; René Assenberg; Jingshan Ren; Sarah Sainsbury; Raymond J Owens; David I Stuart; Jonathan M Grimes; Karl Harlos
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-12-20

2.  Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication.

Authors:  René Assenberg; Eloise Mastrangelo; Thomas S Walter; Anil Verma; Mario Milani; Raymond J Owens; David I Stuart; Jonathan M Grimes; Erika J Mancini
Journal:  J Virol       Date:  2009-09-30       Impact factor: 5.103

Review 3.  Functional interplay among the flavivirus NS3 protease, helicase, and cofactors.

Authors:  Kuohan Li; Wint Wint Phoo; Dahai Luo
Journal:  Virol Sin       Date:  2014-03-26       Impact factor: 4.327

4.  Structure based drug designing of a novel antiflaviviral inhibitor for nonstructural 3 protein.

Authors:  Singh Jitendra; Randhawa Vinay
Journal:  Bioinformation       Date:  2011-03-26

5.  Structure of the NS3 helicase from Zika virus.

Authors:  Rinku Jain; Javier Coloma; Adolfo García-Sastre; Aneel K Aggarwal
Journal:  Nat Struct Mol Biol       Date:  2016-07-11       Impact factor: 15.369

6.  Illustrating and homology modeling the proteins of the Zika virus.

Authors:  Sean Ekins; John Liebler; Bruno J Neves; Warren G Lewis; Megan Coffee; Rachelle Bienstock; Christopher Southan; Carolina H Andrade
Journal:  F1000Res       Date:  2016-03-03

7.  Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling.

Authors:  Dimitrios Vlachakis
Journal:  Theor Biol Med Model       Date:  2009-06-25       Impact factor: 2.432

8.  Antiviral potential of 4-hydroxypanduratin A, secondary metabolite of Fingerroot, Boesenbergia pandurata (Schult.), towards Japanese Encephalitis virus NS2B/NS3 protease.

Authors:  Chandrabhan Seniya; Harshal Mishra; Ajay Yadav; Nitin Sagar; Babita Chaturvedi; Kuldeep Uchadia; Gulshan Wadhwa
Journal:  Bioinformation       Date:  2013-01-09

9.  Rhabdovirus matrix protein structures reveal a novel mode of self-association.

Authors:  Stephen C Graham; René Assenberg; Olivier Delmas; Anil Verma; Alireza Gholami; Chiraz Talbi; Raymond J Owens; David I Stuart; Jonathan M Grimes; Hervé Bourhy
Journal:  PLoS Pathog       Date:  2008-12-26       Impact factor: 6.823

Review 10.  Structure and functionality in flavivirus NS-proteins: perspectives for drug design.

Authors:  Michela Bollati; Karin Alvarez; René Assenberg; Cécile Baronti; Bruno Canard; Shelley Cook; Bruno Coutard; Etienne Decroly; Xavier de Lamballerie; Ernest A Gould; Gilda Grard; Jonathan M Grimes; Rolf Hilgenfeld; Anna M Jansson; Hélène Malet; Erika J Mancini; Eloise Mastrangelo; Andrea Mattevi; Mario Milani; Grégory Moureau; Johan Neyts; Raymond J Owens; Jingshan Ren; Barbara Selisko; Silvia Speroni; Holger Steuber; David I Stuart; Torsten Unge; Martino Bolognesi
Journal:  Antiviral Res       Date:  2009-11-27       Impact factor: 5.970
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