Literature DB >> 178923

Fluorosugars inhibit biological properties of different enveloped viruses.

M F Schmidt, R T Schwarz, H Ludwig.   

Abstract

Both 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose were found to be potent inhibitors of the synthesis of infectious Semliki forest and fowl plague virus in chicken embryo cells and also of pseudorabies virus grown in rabbit kidney cells. It was found that the pseudorabies virus-mediated cell fusion and the synthesis of functional hemagglutinin of fowl plague virus were blocked. In all cases the 2-deoxy-2-fluoro-D-mannose-caused inhibition was stronger than the 2-deoxy-2-fluoro-D-glucose- or 2-deoxy-D-glucose-mediated blocks. Studies on the virus-specified proteins from Semiliki forest virus-infected cells grown in the presence of the inhibitors show that the target of the fluorosugar action, parallel to the well-studied effects of 2-deoxy-D-glucose, is the glycoprotein biosynthesis.

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Year:  1976        PMID： 178923      PMCID： PMC354779     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Monolayer tissue cultures. I. Preparation and standardization of suspensions of trypsin-dispersed monkey kidney cells.

Authors:  J S YOUNGNER
Journal:  Proc Soc Exp Biol Med       Date:  1954-02

2.  Incorporation of 2-deoxy-D-glucose into glucoproteins of normal and Simian virus 40-transformed hamster cells.

Authors:  S Steiner; R J Courtney; J L Melnick
Journal:  Cancer Res       Date:  1973-10       Impact factor: 12.701

3.  The proteins of the parainfluenza virus SV5. II. The carbohydrate content and glycoproteins of the virion.

Authors:  H D Klenk; L A Caliguiri; P W Choppin
Journal:  Virology       Date:  1970-10       Impact factor: 3.616

4.  Inhibition of glycolysis in ascites tumor cells preincubated with 2 -deoxy- 2-fluoro- D -glucose.

Authors:  E L Coe
Journal:  Biochim Biophys Acta       Date:  1972-04-21

5.  Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells.

Authors:  M F Schmidt; R T Schwarz; C Scholtissek
Journal:  Eur J Biochem       Date:  1974-11-01

6.  Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.

Authors:  H D Klenk; C Scholtissek; R Rott
Journal:  Virology       Date:  1972-09       Impact factor: 3.616

7.  Lysis of Saccharomyces cerevisiae with 2-deoxy-2-fluoro-D-glucose, an inhibitor of the cell wall glucan synthesis.

Authors:  P Biely; J Kovarik; S Bauer
Journal:  J Bacteriol       Date:  1973-09       Impact factor: 3.490

8.  Physical and biological properties of influenza virus components obtained after ether treatment.

Authors:  F M DAVENPORT; R ROTT; W SCHAEFER
Journal:  J Exp Med       Date:  1960-11-01       Impact factor: 14.307

9.  The use of deoxyfluoro-D-glucopyranoses and related compounds in a study of yeast hexokinase specificity.

Authors:  E M Bessell; A B Foster; J H Westwood
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857

10.  Inhibition of glycosylation of the influenza virus hemagglutinin.

Authors:  R T Schwarz; H D Klenk
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103
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  11 in total

1.  Inhibition of Rous sarcoma virus replication by 2-deoxyglucose and tunicamycin: identification of an unglycosylated env gene product.

Authors:  R Stohrer; E Hunter
Journal:  J Virol       Date:  1979-11       Impact factor: 5.103

2.  Effect of tunicamyein on the morphogenesis of Semliki Forest virus and Rous sarcoma virus.

Authors:  H Ogura; M F Schmidt; R T Schwarz
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

3.  Involvement of actin-containing microfilaments in HSV-induced cytopathology and the influence of inhibitors of glycosylation.

Authors:  U Heeg; H P Dienes; S Müller; D Falke
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

4.  Carbohydrates of influenza virus. I. Glycopeptides derived from viral glycoproteins after labeling with radioactive sugars.

Authors:  R T Schwarz; M F Schmidt; U Anwer; H D Klenk
Journal:  J Virol       Date:  1977-08       Impact factor: 5.103

5.  Interference with glycosylation of glycoproteins. Inhibition of formation of lipid-linked oligosaccharides in vivo.

Authors:  R Datema; R T Schwarz
Journal:  Biochem J       Date:  1979-10-15       Impact factor: 3.857

6.  Inhibition of herpes simplex virus replication by methyl daunosamine.

Authors:  J G Spivack; W H Prusoff; T R Tritton
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

Review 7.  Viral glycoprotein metabolism as a target for antiviral substances.

Authors:  H D Klenk; R T Schwarz
Journal:  Antiviral Res       Date:  1982-09       Impact factor: 5.970

8.  Suppression of glycoprotein formation of Semliki Forest, influenza, and avian sarcoma virus by tunicamycin.

Authors:  R T Schwarz; J M Rohrschneider; M F Schmidt
Journal:  J Virol       Date:  1976-09       Impact factor: 5.103

9.  Incorporation of N-fluoroacetyl-D-glucosamine into hyaluronate by rabbit tracheal explants in organ culture.

Authors:  D J Winterbourne; R J Barnaby; P W Kent; N Mian
Journal:  Biochem J       Date:  1979-09-15       Impact factor: 3.857

10.  Effect of cytochalasin B on the maturation of enveloped viruses.

Authors:  J A Griffin; R W Compans
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307
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