Literature DB >> 17889422

The role of intracellular amyloid beta in Alzheimer's disease.

Meng Li1, Liying Chen, Daniel Hong Seng Lee, Long-Chuan Yu, Yan Zhang.   

Abstract

Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.

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Year:  2007        PMID： 17889422     DOI： 10.1016/j.pneurobio.2007.08.002

Source DB:  PubMed          Journal:  Prog Neurobiol        ISSN： 0301-0082            Impact factor:   11.685


  39 in total

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Review 2.  Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.

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3.  Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.

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5.  Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.

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6.  Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.

Authors:  Alex E Roher; Chera L Maarouf; Michael Malek-Ahmadi; Jeffrey Wilson; Tyler A Kokjohn; Ian D Daugs; Charisse M Whiteside; Walter M Kalback; Mimi P Macias; Sandra A Jacobson; Marwan N Sabbagh; Bernardino Ghetti; Thomas G Beach
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7.  Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease.

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8.  Increased accumulation of intraneuronal amyloid beta in HIV-infected patients.

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Journal:  J Neuroimmune Pharmacol       Date:  2009-03-17       Impact factor: 4.147

9.  Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.

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10.  Robustness in regulatory interaction networks. A generic approach with applications at different levels: physiologic, metabolic and genetic.

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