| Literature DB >> 17888662 |
Yan-bo Tang1, Zong-gen Peng, Zong-ying Liu, Yan-ping Li, Jian-dong Jiang, Zhuo-rong Li.
Abstract
A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral agents. The antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent antiviral activities. The IC(50) of 5f for HBV was 2.15 microM, and the IC(50) of 5g for HIV-1 was 1.61 microM.Entities:
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Year: 2007 PMID： 17888662 DOI： 10.1016/j.bmcl.2007.08.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823