Literature DB >> 17888129

The importance of TCF7L2.

M N Weedon1.   

Abstract

After many years of frustratingly limited success, the genetic architecture of Type 2 diabetes is finally being uncovered. Recent genome-wide association studies have identified novel genes predisposing to Type 2 diabetes, which are giving fascinating new insights into the pathophysiology of this complex disease. Of the genes so far identified by this approach, one stands out as having by far the biggest effect on disease risk. A common variant of TCF7L2, when present in two copies, is associated with an approximate 2-fold higher risk of Type 2 diabetes. This short review focuses on the TCF7L2 finding and discusses its significance for Type 2 diabetes genetic studies and for clinical practice.

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Year:  2007        PMID： 17888129     DOI： 10.1111/j.1464-5491.2007.02258.x

Source DB:  PubMed          Journal:  Diabet Med        ISSN： 0742-3071            Impact factor:   4.359


  30 in total

1.  Sideways Glance: Genome wide association studies for type 2 diabetes mellitus.

Authors:  Yula Sambuy
Journal:  Genes Nutr       Date:  2007-12       Impact factor: 5.523

2.  Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line.

Authors:  Yao Wang; Rui Wang; Victor X Jin
Journal:  Int J Comput Biol Drug Des       Date:  2016

3.  Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits.

Authors:  Melis A Aksit; Rhonda G Pace; Briana Vecchio-Pagán; Hua Ling; Johanna M Rommens; Pierre-Yves Boelle; Loic Guillot; Karen S Raraigh; Elizabeth Pugh; Peng Zhang; Lisa J Strug; Mitch L Drumm; Michael R Knowles; Garry R Cutting; Harriet Corvol; Scott M Blackman
Journal:  J Clin Endocrinol Metab       Date:  2020-05-01       Impact factor: 5.958

Review 4.  Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.

Authors:  Kevin J Basile; Vanessa C Guy; Stanley Schwartz; Struan F A Grant
Journal:  Curr Diab Rep       Date:  2014       Impact factor: 4.810

5.  Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

Authors:  Rosalind J Neuman; Jon Wasson; Gil Atzmon; Julio Wainstein; Yair Yerushalmi; Joseph Cohen; Nir Barzilai; Ilana Blech; Benjamin Glaser; M Alan Permutt
Journal:  PLoS One       Date:  2010-03-26       Impact factor: 3.240

6.  Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.

Authors:  Roberto Gambino; Simona Bo; Luigi Gentile; Giovanni Musso; Gianfranco Pagano; Paolo Cavallo-Perin; Maurizio Cassader
Journal:  Diabetes Care       Date:  2010-03-18       Impact factor: 17.152

Review 7.  The WNT signalling pathway and diabetes mellitus.

Authors:  T Jin
Journal:  Diabetologia       Date:  2008-08-12       Impact factor: 10.122

8.  Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.

Authors:  Konstantinos K Tsilidis; Kathy J Helzlsouer; Michael W Smith; Victoriya Grinberg; Judith Hoffman-Bolton; Sandra L Clipp; Kala Visvanathan; Elizabeth A Platz
Journal:  Cancer Causes Control       Date:  2009-11       Impact factor: 2.506

9.  Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.

Authors:  Anna L Gloyn; Matthias Braun; Patrik Rorsman
Journal:  Diabetes       Date:  2009-04       Impact factor: 9.461

10.  Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.

Authors:  Dennis O Mook-Kanamori; Sandra W K de Kort; Cornelia M van Duijn; Andre G Uitterlinden; Albert Hofman; Henriëtte A Moll; Eric A P Steegers; Anita C S Hokken-Koelega; Vincent W V Jaddoe
Journal:  BMC Med Genet       Date:  2009-07-17       Impact factor: 2.103
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