OBJECTIVE AND METHODS: The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated. Haplotype tagging SNPs were chosen for IL10, CRP, and TLR4. Incident colorectal cancer cases (n = 208) and matched controls (n = 381) were identified between baseline in 1989 and 2003 among participants in the CLUE II cohort. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with the AA genotype at the candidate IL10-1082 locus (rs1800896), carrying one (OR, 0.79; 95% CI, 0.53-1.18) or two (OR, 0.58; 95% CI, 0.35-0.95) G alleles, a known higher producer of the anti-inflammatory cytokine IL-10, was associated with lower risk of colorectal cancer (p trend = 0.03). Statistically significant associations with colorectal cancer were observed for three tagSNPs in IL10 (rs1800890, rs3024496, rs3024498) and one common haplotype, but these associations were due to high linkage disequilibrium with IL10-1082. Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer. CONCLUSIONS: Our study suggests that polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
OBJECTIVE AND METHODS: The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated. Haplotype tagging SNPs were chosen for IL10, CRP, and TLR4. Incident colorectal cancer cases (n = 208) and matched controls (n = 381) were identified between baseline in 1989 and 2003 among participants in the CLUE II cohort. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with the AA genotype at the candidate IL10-1082 locus (rs1800896), carrying one (OR, 0.79; 95% CI, 0.53-1.18) or two (OR, 0.58; 95% CI, 0.35-0.95) G alleles, a known higher producer of the anti-inflammatory cytokine IL-10, was associated with lower risk of colorectal cancer (p trend = 0.03). Statistically significant associations with colorectal cancer were observed for three tagSNPs in IL10 (rs1800890, rs3024496, rs3024498) and one common haplotype, but these associations were due to high linkage disequilibrium with IL10-1082. Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer. CONCLUSIONS: Our study suggests that polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
Authors: Daniel J Schaid; Charles M Rowland; David E Tines; Robert M Jacobson; Gregory A Poland Journal: Am J Hum Genet Date: 2001-12-27 Impact factor: 11.025
Authors: Esther K Wei; Jing Ma; Michael N Pollak; Nader Rifai; Charles S Fuchs; Susan E Hankinson; Edward Giovannucci Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-04 Impact factor: 4.254
Authors: Virginia G Kaklamani; Kari B Wisinski; Maureen Sadim; Cassandra Gulden; Albert Do; Kenneth Offit; John A Baron; Habibul Ahsan; Christos Mantzoros; Boris Pasche Journal: JAMA Date: 2008-10-01 Impact factor: 56.272
Authors: Aditi Hazra; Charles S Fuchs; Andrew T Chan; Edward L Giovannucci; David J Hunter Journal: Cancer Causes Control Date: 2008-05-14 Impact factor: 2.506
Authors: Konstantinos K Tsilidis; Casey Branchini; Eliseo Guallar; Kathy J Helzlsouer; Thomas P Erlinger; Elizabeth A Platz Journal: Int J Cancer Date: 2008-09-01 Impact factor: 7.396
Authors: Andre Franke; Tobias Balschun; Tom H Karlsen; Jurgita Sventoraityte; Susanna Nikolaus; Gabriele Mayr; Francisco S Domingues; Mario Albrecht; Michael Nothnagel; David Ellinghaus; Christian Sina; Clive M Onnie; Rinse K Weersma; Pieter C F Stokkers; Cisca Wijmenga; Maria Gazouli; David Strachan; Wendy L McArdle; Séverine Vermeire; Paul Rutgeerts; Philip Rosenstiel; Michael Krawczak; Morten H Vatn; Christopher G Mathew; Stefan Schreiber Journal: Nat Genet Date: 2008-10-05 Impact factor: 38.330
Authors: J C Hardwick; G R Van Den Brink; G J Offerhaus; S J Van Deventer; M P Peppelenbosch Journal: Gastroenterology Date: 2001-07 Impact factor: 22.682
Authors: Cindy M Chang; Victoria M Chia; Marc J Gunter; Krista A Zanetti; Bríd M Ryan; Julie E Goodman; Curtis C Harris; Joel Weissfeld; Wen-Yi Huang; Stephen Chanock; Meredith Yeager; Richard B Hayes; Sonja I Berndt Journal: Carcinogenesis Date: 2013-06-26 Impact factor: 4.944
Authors: Hansong Wang; Darin Taverna; Daniel O Stram; Barbara K Fortini; Iona Cheng; Lynne R Wilkens; Terrilea Burnett; Karen W Makar; Noralane M Lindor; John L Hopper; Steve Gallinger; John A Baron; Robert Haile; Laurence N Kolonel; Brian E Henderson; Polly A Newcomb; Graham Casey; David Duggan; Cornelia M Ulrich; Loïc Le Marchand Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-09-17 Impact factor: 4.254
Authors: Katharine N Sourbeer; Lauren E Howard; Gerald L Andriole; Daniel M Moreira; Ramiro Castro-Santamaria; Stephen J Freedland; Adriana C Vidal Journal: BJU Int Date: 2014-10-20 Impact factor: 5.588