| Literature DB >> 17888010 |
Souwalak Phongpaichit1, Jaru Nikom, Nattawut Rungjindamai, Jariya Sakayaroj, Nongporn Hutadilok-Towatana, Vatcharin Rukachaisirikul, Kanyawim Kirtikara.
Abstract
Sixty-five crude extracts from 51 selected endophytic fungi isolated from Garcinia species were tested for various bioactivities. Eighty per cent of the fungal extracts from fermentation broths and mycelia displayed bioactivities: antimycobacterial (76.9%), antimalarial (14.1%), antiviral (16.7%), antioxidant (22.2%), antiproliferation (11.1% against NCI-H187 and 12.7% against KB cells), and cytotoxicity to Vero cells (40.0%). Based on internal transcribed spacer rRNA sequence analysis, 15 bioactive isolates were identified as Aspergillus, Botryosphaeria, Curvularia, Fusicoccum, Guignardia, Muscodor, Penicillium, Pestalotiopsis, and Phomopsis spp. One isolate (N24) was matched with an unidentified fungal endophyte. These results indicate that endophytic fungi isolated from Garcinia plants in Thailand are potential sources of various bioactive natural products.Entities:
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Year: 2007 PMID： 17888010 DOI： 10.1111/j.1574-695X.2007.00331.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244