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Literature DB >> 17875991

Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.

Ruqaiyyah Siddiqui¹, Abdul Matin, David Warhurst, Monique Stins, Naveed Ahmed Khan.

Abstract

Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17875991 PMCID： PMC2168013 DOI： 10.1128/AAC.00373-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

Review 1. Balamuthia mandrillaris: its pathogenic potential.

Authors: A J Martínez; F L Schuster; G S Visvesvara
Journal: J Eukaryot Microbiol Date: 2001 Impact factor: 3.346

2. Acanthamoeba interactions with human brain microvascular endothelial cells.

Authors: Selwa Alsam; Kwang Sik Kim; Monique Stins; Antonio Ortega Rivas; James Sissons; Naveed Ahmed Khan
Journal: Microb Pathog Date: 2003-12 Impact factor: 3.738

3. Axenic growth and drug sensitivity studies of Balamuthia mandrillaris, an agent of amebic meningoencephalitis in humans and other animals.

Authors: F L Schuster; G S Visvesvara
Journal: J Clin Microbiol Date: 1996-02 Impact factor: 5.948

4. Neurotoxic mode of action of artemisinin.

Authors: Gabriele Schmuck; Elke Roehrdanz; Richard K Haynes; Regine Kahl
Journal: Antimicrob Agents Chemother Date: 2002-03 Impact factor: 5.191

Review 5. Opportunistic amoebae: challenges in prophylaxis and treatment.

Authors: Frederick L Schuster; Govinda S Visvesvara
Journal: Drug Resist Updat Date: 2004-02 Impact factor: 18.500

6. Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.

Authors: Samantha Jayasekera; James Sissons; Julie Tucker; Claire Rogers; Debbie Nolder; David Warhurst; Selwa Alsam; Jonathan M L White; E M Higgins; Naveed Ahmed Khan
Journal: J Med Microbiol Date: 2004-10 Impact factor: 2.472

7. 7-Dehydrostigmasterol and ergosterol: the major sterols of an amoeba.

Authors: F R Smith; E D Korn
Journal: J Lipid Res Date: 1968-07 Impact factor: 5.922

8. Genotyping of Balamuthia mandrillaris based on nuclear 18S and mitochondrial 16S rRNA genes.

Authors: Gregory C Booton; Jennifer R Carmichael; Govinda S Visvesvara; Thomas J Byers; Paul A Fuerst
Journal: Am J Trop Med Hyg Date: 2003-01 Impact factor: 2.345

Review 9. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea.

Authors: Govinda S Visvesvara; Hercules Moura; Frederick L Schuster
Journal: FEMS Immunol Med Microbiol Date: 2007-04-11

Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.

Review 1. Balamuthia mandrillaris: its pathogenic potential.

2. Acanthamoeba interactions with human brain microvascular endothelial cells.

3. Axenic growth and drug sensitivity studies of Balamuthia mandrillaris, an agent of amebic meningoencephalitis in humans and other animals.

4. Neurotoxic mode of action of artemisinin.

Review 5. Opportunistic amoebae: challenges in prophylaxis and treatment.

6. Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.

7. 7-Dehydrostigmasterol and ergosterol: the major sterols of an amoeba.

8. Genotyping of Balamuthia mandrillaris based on nuclear 18S and mitochondrial 16S rRNA genes.

Review 9. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea.

10. Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga.

1. Disseminated Balamuthia mandrillaris Infection.

2. Development of nanoparticle-assisted PCR assay in the rapid detection of brain-eating amoebae.

3. The cyst wall carbohydrate composition of Balamuthia mandrillaris.

4. Laboratory testing of clinically approved drugs against Balamuthia mandrillaris.

5. Opportunistic free-living amoebal pathogens.

6. Balamuthia mandrillaris: Morphology, biology, and virulence.

7. Balamuthia mandrillaris trophozoites ingest human neuronal cells via a trogocytosis-independent mechanism.

8. Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae.