Literature DB >> 17873883

The structure of bacterial ParM filaments.

Albina Orlova1, Ethan C Garner, Vitold E Galkin, John Heuser, R Dyche Mullins, Edward H Egelman.   

Abstract

Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.

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Year:  2007        PMID： 17873883      PMCID： PMC3541950          DOI： 10.1038/nsmb1300

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  35 in total

1.  Concerning the dynamic instability of actin homolog ParM.

Authors:  David Popp; Akihiro Yamamoto; Mitsusada Iwasa; Akihiro Narita; Kayo Maeda; Yuichiro Maéda
Journal:  Biochem Biophys Res Commun       Date:  2006-12-06       Impact factor: 3.575

2.  Crystal structure of the bacterial cell-division protein FtsZ.

Authors:  J Löwe; L A Amos
Journal:  Nature       Date:  1998-01-08       Impact factor: 49.962

3.  Crystal structure of polymerization-competent actin.

Authors:  Vadim A Klenchin; Sofia Y Khaitlina; Ivan Rayment
Journal:  J Mol Biol       Date:  2006-08-07       Impact factor: 5.469

4.  The iterative helical real space reconstruction method: surmounting the problems posed by real polymers.

Authors:  Edward H Egelman
Journal:  J Struct Biol       Date:  2006-07-11       Impact factor: 2.867

5.  Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.

Authors:  Dhirendra K Simanshu; H S Savithri; M R N Murthy
Journal:  J Mol Biol       Date:  2005-09-30       Impact factor: 5.469

6.  Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.

Authors:  A E Aleshin; M Malfois; X Liu; C S Kim; H J Fromm; R B Honzatko; M H Koch; D I Svergun
Journal:  Biochemistry       Date:  1999-06-29       Impact factor: 3.162

7.  Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.

Authors:  A E Aleshin; C Zeng; H D Bartunik; H J Fromm; R B Honzatko
Journal:  J Mol Biol       Date:  1998-09-18       Impact factor: 5.469

8.  Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle.

Authors:  R B Jensen; K Gerdes
Journal:  EMBO J       Date:  1999-07-15       Impact factor: 11.598

9.  Dynamic instability in a DNA-segregating prokaryotic actin homolog.

Authors:  Ethan C Garner; Christopher S Campbell; R Dyche Mullins
Journal:  Science       Date:  2004-11-05       Impact factor: 47.728

10.  A change in actin conformation associated with filament instability after Pi release.

Authors:  L D Belmont; A Orlova; D G Drubin; E H Egelman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205
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  42 in total

Review 1.  The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments.

Authors:  Jeanne Salje; Pananghat Gayathri; Jan Löwe
Journal:  Nat Rev Microbiol       Date:  2010-10       Impact factor: 60.633

2.  When cytoskeletal worlds collide.

Authors:  Eva Nogales
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-08       Impact factor: 11.205

Review 3.  Bacterial Filament Systems: Toward Understanding Their Emergent Behavior and Cellular Functions.

Authors:  Ye-Jin Eun; Mrinal Kapoor; Saman Hussain; Ethan C Garner
Journal:  J Biol Chem       Date:  2015-05-08       Impact factor: 5.157

4.  High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex.

Authors:  Vitold E Galkin; Albina Orlova; Olga Cherepanova; Marie-Christine Lebart; Edward H Egelman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-30       Impact factor: 11.205

5.  Molecular structure of the ParM polymer and the mechanism leading to its nucleotide-driven dynamic instability.

Authors:  David Popp; Akihiro Narita; Toshiro Oda; Tetsuro Fujisawa; Hiroshi Matsuo; Yasushi Nitanai; Mitsusada Iwasa; Kayo Maeda; Hirofumi Onishi; Yuichiro Maéda
Journal:  EMBO J       Date:  2008-01-10       Impact factor: 11.598

6.  Problems in fitting high resolution structures into electron microscopic reconstructions.

Authors:  Edward H Egelman
Journal:  HFSP J       Date:  2008-09-29

7.  The structure of an archaeal pilus.

Authors:  Ying A Wang; Xiong Yu; Sandy Y M Ng; Ken F Jarrell; Edward H Egelman
Journal:  J Mol Biol       Date:  2008-06-12       Impact factor: 5.469

8.  Bacterial actin: architecture of the ParMRC plasmid DNA partitioning complex.

Authors:  Jeanne Salje; Jan Löwe
Journal:  EMBO J       Date:  2008-07-24       Impact factor: 11.598

9.  Superstructure of the centromeric complex of TubZRC plasmid partitioning systems.

Authors:  Christopher H S Aylett; Jan Löwe
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-25       Impact factor: 11.205

10.  Phylogenetic analysis identifies many uncharacterized actin-like proteins (Alps) in bacteria: regulated polymerization, dynamic instability and treadmilling in Alp7A.

Authors:  Alan I Derman; Eric C Becker; Bao D Truong; Akina Fujioka; Timothy M Tucey; Marcella L Erb; Paula C Patterson; Joe Pogliano
Journal:  Mol Microbiol       Date:  2009-07-07       Impact factor: 3.501
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