Literature DB >> 17873847

Synthesis and anti-tumor activities of novel [1,2,4]triazolo[1,5-a]pyrimidines.

Xiang-Lin Zhao1, Yan-Fang Zhao, Shu-Chun Guo, Hai-Sheng Song, Ding Wang, Ping Gong.   

Abstract

A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 microM and 6.1 microM against Bel-7402 and HT-1080 cell lines respectively.

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Year:  2007        PMID： 17873847      PMCID： PMC6149424          DOI： 10.3390/12051136

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  13 in total

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Authors:  Peter Ordentlich; Yingzhuo Yan; Sihong Zhou; Richard A Heyman
Journal:  J Biol Chem       Date:  2003-04-22       Impact factor: 5.157

2.  New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.

Authors:  S Schenone; O Bruno; A Ranise; F Bondavalli; C Brullo; P Fossa; L Mosti; G Menozzi; F Carraro; A Naldini; C Bernini; F Manetti; M Botta
Journal:  Bioorg Med Chem Lett       Date:  2004-05-17       Impact factor: 2.823

3.  Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.

Authors:  Nan Zhang; Semiramis Ayral-Kaloustian; Thai Nguyen; Jay Afragola; Richard Hernandez; Judy Lucas; James Gibbons; Carl Beyer
Journal:  J Med Chem       Date:  2007-01-25       Impact factor: 7.446

4.  Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

Authors:  M Knockaert; N Gray; E Damiens; Y T Chang; P Grellier; K Grant; D Fergusson; J Mottram; M Soete; J F Dubremetz; K Le Roch; C Doerig; P Schultz; L Meijer
Journal:  Chem Biol       Date:  2000-06

5.  Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.

Authors:  Miguel F Braña; Mónica Cacho; M Luisa García; Elena P Mayoral; Berta López; Beatriz de Pascual-Teresa; Ana Ramos; Nuria Acero; Francisco Llinares; Dolores Muñoz-Mingarro; Olivier Lozach; Laurent Meijer
Journal:  J Med Chem       Date:  2005-11-03       Impact factor: 7.446

6.  Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

Authors:  Marcin Hoffmann; Maria Chrzanowska; Tadeusz Hermann; Jacek Rychlewski
Journal:  J Med Chem       Date:  2005-06-30       Impact factor: 7.446

7.  Roscovitine targets, protein kinases and pyridoxal kinase.

Authors:  Stéphane Bach; Marie Knockaert; Jens Reinhardt; Olivier Lozach; Sophie Schmitt; Blandine Baratte; Marcel Koken; Stephen P Coburn; Lin Tang; Tao Jiang; Dong-Cai Liang; Hervé Galons; Jean-Francois Dierick; Lorenzo A Pinna; Flavio Meggio; Frank Totzke; Christoph Schächtele; Andrea S Lerman; Amancio Carnero; Yongqin Wan; Nathanael Gray; Laurent Meijer
Journal:  J Biol Chem       Date:  2005-06-23       Impact factor: 5.157

8.  Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

Authors:  Jay A Markwalder; Marc R Arnone; Pamela A Benfield; Michael Boisclair; Catherine R Burton; Chong-Hwan Chang; Sarah S Cox; Philip M Czerniak; Charity L Dean; Deborah Doleniak; Robert Grafstrom; Barbara A Harrison; Robert F Kaltenbach; David A Nugiel; Karen A Rossi; Susan R Sherk; Lisa M Sisk; Pieter Stouten; George L Trainor; Peter Worland; Steven P Seitz
Journal:  J Med Chem       Date:  2004-11-18       Impact factor: 7.446

9.  Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.

Authors:  Edward A Monaco; Carol M Beaman-Hall; Anjili Mathur; Mary Lou Vallano
Journal:  Biochem Pharmacol       Date:  2004-05-15       Impact factor: 5.858

10.  Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.

Authors:  Carlos Jaramillo; J Eugenio de Diego; Chafiq Hamdouchi; Elizabeth Collins; Heather Keyser; Concha Sánchez-Martínez; Miriam del Prado; Bryan Norman; Harold B Brooks; Scott A Watkins; Charles D Spencer; Jack Alan Dempsey; Bryan D Anderson; Robert M Campbell; Tellie Leggett; Bharvin Patel; Richard M Schultz; Juan Espinosa; Michal Vieth; Faming Zhang; David E Timm
Journal:  Bioorg Med Chem Lett       Date:  2004-12-20       Impact factor: 2.823
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  5 in total

Review 1.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

2.  A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles.

Authors:  Joana F Campos; Mohammed Loubidi; Marie-Christine Scherrmann; Sabine Berteina-Raboin
Journal:  Molecules       Date:  2018-03-18       Impact factor: 4.411

3.  Synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents.

Authors:  Mosaad S Mohamed; Samir M Awad; Amira Ibrahim Sayed
Journal:  Molecules       Date:  2010-03-15       Impact factor: 4.411

4.  In vivo and In vitro effects of ethanolic extract of Trigonella foenum-graecum L. seeds on proliferation, angiogenesis and tube formation of endothelial cells.

Authors:  Mozhdeh Iranmanesh; Reza Mohebbati; Fatemeh Forouzanfar; Mostafa Karimi Roshan; Ahmad Ghorbani; Mohammad Jalili Nik; Mohammad Soukhtanloo
Journal:  Res Pharm Sci       Date:  2018-08

5.  4-Methyl-2,6-bis-(pyrrolidin-1-yl)pyrimidine.

Authors:  S Sreenivasa; K E Manojkumar; M Shet Prakash; P A Suchetan; B S Palakshamurthy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24
  5 in total

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