Literature DB >> 15109642

New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.

S Schenone1, O Bruno, A Ranise, F Bondavalli, C Brullo, P Fossa, L Mosti, G Menozzi, F Carraro, A Naldini, C Bernini, F Manetti, M Botta.   

Abstract

New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.

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Year:  2004        PMID： 15109642     DOI： 10.1016/j.bmcl.2004.03.013

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

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Journal:  ACS Med Chem Lett       Date:  2012-02-09       Impact factor: 4.345

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Journal:  J Med Chem       Date:  2006-06-01       Impact factor: 7.446

3.  New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells.

Authors:  Alessandra Rossi; Silvia Schenone; Adriano Angelucci; Martina Cozzi; Valentina Caracciolo; Francesca Pentimalli; Andrew Puca; Biagio Pucci; Raffaele La Montagna; Mauro Bologna; Maurizio Botta; Antonio Giordano
Journal:  FASEB J       Date:  2010-03-30       Impact factor: 5.191

4.  Src family kinase involvement in rat preglomerular microvascular contractile and [Ca2+]i responses to ANG II.

Authors:  Qi Che; Pamela K Carmines
Journal:  Am J Physiol Renal Physiol       Date:  2004-11-30

5.  Synthesis and anti-tumor activities of novel [1,2,4]triazolo[1,5-a]pyrimidines.

Authors:  Xiang-Lin Zhao; Yan-Fang Zhao; Shu-Chun Guo; Hai-Sheng Song; Ding Wang; Ping Gong
Journal:  Molecules       Date:  2007-05-25       Impact factor: 4.411

6.  Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivates.

Authors:  R Morisi; M Celano; E Tosi; S Schenone; M Navarra; E Ferretti; G Costante; C Durante; G Botta; M D'Agostino; C Brullo; S Filetti; M Botta; D Russo
Journal:  J Endocrinol Invest       Date:  2007-11       Impact factor: 4.256

7.  Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors.

Authors:  Amir Nasrolahi Shirazi; Rakesh Kumar Tiwari; Alex Brown; Dindyal Mandal; Gongqin Sun; Keykavous Parang
Journal:  Bioorg Med Chem Lett       Date:  2013-04-06       Impact factor: 2.823

8.  Cyclic Peptides as Protein Kinase Inhibitors: Structure-Activity Relationship and Molecular Modeling.

Authors:  Michel F Sanner; Khalid Zoghebi; Samara Hanna; Saghar Mozaffari; Simin Rahighi; Rakesh K Tiwari; Keykavous Parang
Journal:  J Chem Inf Model       Date:  2021-05-17       Impact factor: 6.162

9.  4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities.

Authors:  Ali Rafinejad; Asal Fallah-Tafti; Rakesh Tiwari; Amir Nasrolahi Shirazi; Deendayal Mandal; Abbas Shafiee; Keykavous Parang; Alireza Foroumadi; Tahmineh Akbarzadeh
Journal:  Daru       Date:  2012-12-26       Impact factor: 3.117

10.  SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation.

Authors:  Nadia Casini; Iris Maria Forte; Gianmarco Mastrogiovanni; Francesca Pentimalli; Adriano Angelucci; Claudio Festuccia; Valentina Tomei; Elisa Ceccherini; Domenico Di Marzo; Silvia Schenone; Maurizio Botta; Antonio Giordano; Paola Indovina
Journal:  Oncotarget       Date:  2015-05-20
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