Classification of protein folds.

The diversity and complexity of bioinformatics tools currently available for protein sequence analysis can make it difficult to know where to begin when presented with a new sequence. In this article, we present a protocol outlining one approach to sequence analysis that should give as comprehensive a picture as possible as to the likely structure and function of a protein given the limits of available tools. We also provide worked examples showing how these tools can have an impact on the understanding of protein function prior to experimental studies.