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Literature DB >> 17873350

Breast cancer stem cells-research opportunities utilizing mathematical modeling.

Rina Ashkenazi¹, Trachette L Jackson, Gabriela Dontu, Max S Wicha.

Abstract

There is increasing evidence for the "cancer stem cell hypothesis" which holds that cancers originate in tissue stem cells or progenitor cells. As a result of this, cancers are driven by a cellular subcomponent that retains stem cell properties. Among these properties are self-renewal and multi-lineage differentiation. The biological processes which account for stem cell properties are currently being elucidated. Cancer stem cells maintain many of the same characteristics of their normal counterparts. The combination of biological research with mathematical modeling may provide for a greater understanding of the complex picture of breast cancer stem cells and assist cancer biologists and clinical oncologists in designing and testing novel therapeutic strategies.

Entities: Disease

Mesh：

Year: 2007 PMID： 17873350 DOI： 10.1007/s12015-007-0026-2

Source DB: PubMed Journal: Stem Cell Rev ISSN： 1550-8943 Impact factor: 5.739

31 in total

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Journal: Nat Rev Cancer Date: 2003-12 Impact factor: 60.716

3. Predicting the course of Gompertzian growth.

Authors: L Norton; R Simon; H D Brereton; A E Bogden
Journal: Nature Date: 1976-12-09 Impact factor: 49.962

Review 4. Epidemiology and the causes of breast cancer.

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Journal: Int J Cancer Date: 2006-05-15 Impact factor: 7.396

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Authors: Larry Norton
Journal: Oncologist Date: 2005 Jun-Jul

6. The Norton-Simon hypothesis revisited.

Authors: L Norton; R Simon
Journal: Cancer Treat Rep Date: 1986-01

7. Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.

Authors: Rina Ashkenazi; Sara N Gentry; Trachette L Jackson
Journal: Neoplasia Date: 2008-11 Impact factor: 5.715

Review 8. Treatment options for chronic myeloid leukemia: imatinib versus interferon versus allogeneic transplant.

Authors: Greg R Angstreich; B Douglas Smith; Richard J Jones
Journal: Curr Opin Oncol Date: 2004-03 Impact factor: 3.645

9. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.

Authors: Gabriela Dontu; Kyle W Jackson; Erin McNicholas; Mari J Kawamura; Wissam M Abdallah; Max S Wicha
Journal: Breast Cancer Res Date: 2004-08-16 Impact factor: 6.466

Review 10. Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'.

Authors: Thomas B L Kirkwood
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2015-04-19 Impact factor: 6.237

6 in total

1. Cell type-specific DNA methylation patterns in the human breast.

Authors: Noga Bloushtain-Qimron; Jun Yao; Eric L Snyder; Michail Shipitsin; Lauren L Campbell; Sendurai A Mani; Min Hu; Haiyan Chen; Vadim Ustyansky; Jessica E Antosiewicz; Pedram Argani; Marc K Halushka; James A Thomson; Paul Pharoah; Angel Porgador; Saraswati Sukumar; Ramon Parsons; Andrea L Richardson; Martha R Stampfer; Rebecca S Gelman; Tatiana Nikolskaya; Yuri Nikolsky; Kornelia Polyak
Journal: Proc Natl Acad Sci U S A Date: 2008-09-09 Impact factor: 11.205