Literature DB >> 17873058

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event.

Rashna Bhandari1, Adolfo Saiardi, Yousef Ahmadibeni, Adele M Snowman, Adam C Resnick, Troels Z Kristiansen, Henrik Molina, Akhilesh Pandey, J Kent Werner, Krishna R Juluri, Yong Xu, Glenn D Prestwich, Keykavous Parang, Solomon H Snyder.   

Abstract

In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP(7)) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphate transfer reflects pyrophosphorylation. Thus, proteins must be prephosphorylated by ATP to prime them for IP(7) phosphorylation. IP(7) phosphorylates synthetic phosphopeptides but not if their phosphates have been masked by methylation or pyrophosphorylation. Moreover, IP(7) phosphorylated peptides are more acid-labile and more resistant to phosphatases than ATP phosphorylated peptides, indicating a different type of phosphate bond. Pyrophosphorylation may represent a novel mode of signaling to proteins.

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Year:  2007        PMID： 17873058      PMCID： PMC2000531          DOI： 10.1073/pnas.0707338104

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Phosphate stabilization of intermolecular interactions.

Authors:  Shelley N Jackson; Hay-Yan J Wang; Alfred Yergey; Amina S Woods
Journal:  J Proteome Res       Date:  2006-01       Impact factor: 4.466

2.  The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).

Authors:  L Stephens; T Radenberg; U Thiel; G Vogel; K H Khoo; A Dell; T R Jackson; P T Hawkins; G W Mayr
Journal:  J Biol Chem       Date:  1993-02-25       Impact factor: 5.157

3.  Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases.

Authors:  Adolfo Saiardi; Adam C Resnick; Adele M Snowman; Beverly Wendland; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-21       Impact factor: 11.205

4.  Comparison of the rat nucleolar protein nopp140 with its yeast homolog SRP40. Differential phosphorylation in vertebrates and yeast.

Authors:  U T Meier
Journal:  J Biol Chem       Date:  1996-08-09       Impact factor: 5.157

5.  Phosphorylation of proteins by inositol pyrophosphates.

Authors:  Adolfo Saiardi; Rashna Bhandari; Adam C Resnick; Adele M Snowman; Solomon H Snyder
Journal:  Science       Date:  2004-12-17       Impact factor: 47.728

6.  Inositol diphosphate signaling regulates telomere length.

Authors:  Sally J York; Blaine N Armbruster; Patricia Greenwell; Thomas D Petes; John D York
Journal:  J Biol Chem       Date:  2004-11-23       Impact factor: 5.157

7.  Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.

Authors:  Eiichiro Nagata; Hongbo R Luo; Adolfo Saiardi; Byoung-Il Bae; Norihiro Suzuki; Solomon H Snyder
Journal:  J Biol Chem       Date:  2004-11-08       Impact factor: 5.157

8.  A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

Authors:  S T Safrany; J J Caffrey; X Yang; M E Bembenek; M B Moyer; W A Burkhart; S B Shears
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598

9.  Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.

Authors:  L C Tarshis; M Yan; C D Poulter; J C Sacchettini
Journal:  Biochemistry       Date:  1994-09-13       Impact factor: 3.162

10.  Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.

Authors:  F S Menniti; R N Miller; J W Putney; S B Shears
Journal:  J Biol Chem       Date:  1993-02-25       Impact factor: 5.157
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  90 in total

1.  Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Authors:  Huanchen Wang; Vasudha S Nair; Ashley A Holland; Samanta Capolicchio; Henning J Jessen; Michael K Johnson; Stephen B Shears
Journal:  Biochemistry       Date:  2015-10-09       Impact factor: 3.162

2.  Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.

Authors:  Rajagopal S Kilari; Jeremy D Weaver; Stephen B Shears; Stephen T Safrany
Journal:  FEBS Lett       Date:  2013-09-08       Impact factor: 4.124

Review 3.  Diphosphoinositol polyphosphates: what are the mechanisms?

Authors:  Stephen B Shears; Nikhil A Gokhale; Huanchen Wang; Angelika Zaremba
Journal:  Adv Enzyme Regul       Date:  2010-10-28

4.  A molecular dynamics investigation of lipid bilayer perturbation by PIP2.

Authors:  Dmitry Lupyan; Mihaly Mezei; Diomedes E Logothetis; Roman Osman
Journal:  Biophys J       Date:  2010-01-20       Impact factor: 4.033

5.  HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

Authors:  Anutosh Chakraborty; Michael A Koldobskiy; Katherine M Sixt; Krishna R Juluri; Asif K Mustafa; Adele M Snowman; Damian B van Rossum; Randen L Patterson; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-14       Impact factor: 11.205

6.  Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

Authors:  Chunfang Gu; Michael A Stashko; Ana C Puhl-Rubio; Molee Chakraborty; Anutosh Chakraborty; Stephen V Frye; Kenneth H Pearce; Xiaodong Wang; Stephen B Shears; Huanchen Wang
Journal:  J Med Chem       Date:  2019-01-25       Impact factor: 7.446

7.  Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Authors:  Chenglai Fu; Jing Xu; Weiwei Cheng; Tomas Rojas; Alfred C Chin; Adele M Snowman; Maged M Harraz; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-02       Impact factor: 11.205

8.  The long-awaited demonstration of protein pyrophosphorylation by IP7 in vivo?

Authors:  Stephen Shears
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-02       Impact factor: 11.205

9.  Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways.

Authors:  A Chakraborty; C Latapy; J Xu; S H Snyder; J-M Beaulieu
Journal:  Mol Psychiatry       Date:  2013-02-26       Impact factor: 15.992

10.  Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Authors:  Hongying Lin; Peter C Fridy; Anthony A Ribeiro; Jae H Choi; Deb K Barma; Günter Vogel; J R Falck; Stephen B Shears; John D York; Georg W Mayr
Journal:  J Biol Chem       Date:  2008-11-03       Impact factor: 5.157
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