Literature DB >> 15604408

Phosphorylation of proteins by inositol pyrophosphates.

Adolfo Saiardi1, Rashna Bhandari, Adam C Resnick, Adele M Snowman, Solomon H Snyder.   

Abstract

The inositol pyrophosphates IP7 and IP8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP7, we detected phosphorylation of multiple eukaryotic proteins. We also observed phosphorylation of endogenous proteins by endogenous IP7 in yeast. Phosphorylation by IP7 is nonenzymatic and may represent a novel intracellular signaling mechanism.

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Year:  2004        PMID： 15604408     DOI： 10.1126/science.1103344

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  122 in total

1.  Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Authors:  Huanchen Wang; Vasudha S Nair; Ashley A Holland; Samanta Capolicchio; Henning J Jessen; Michael K Johnson; Stephen B Shears
Journal:  Biochemistry       Date:  2015-10-09       Impact factor: 3.162

Review 2.  Diphosphoinositol polyphosphates: what are the mechanisms?

Authors:  Stephen B Shears; Nikhil A Gokhale; Huanchen Wang; Angelika Zaremba
Journal:  Adv Enzyme Regul       Date:  2010-10-28

Review 3.  Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.

Authors:  Karsten Sauer; Michael P Cooke
Journal:  Nat Rev Immunol       Date:  2010-04       Impact factor: 53.106

Review 4.  Pharmacology of intracellular signalling pathways.

Authors:  Stefan R Nahorski
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

5.  HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

Authors:  Anutosh Chakraborty; Michael A Koldobskiy; Katherine M Sixt; Krishna R Juluri; Asif K Mustafa; Adele M Snowman; Damian B van Rossum; Randen L Patterson; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-14       Impact factor: 11.205

6.  Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Authors:  Chenglai Fu; Jing Xu; Weiwei Cheng; Tomas Rojas; Alfred C Chin; Adele M Snowman; Maged M Harraz; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-02       Impact factor: 11.205

7.  The long-awaited demonstration of protein pyrophosphorylation by IP7 in vivo?

Authors:  Stephen Shears
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-02       Impact factor: 11.205

8.  Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.

Authors:  Boris Topolski; Visnja Jakopec; Natascha A Künzel; Ursula Fleig
Journal:  Mol Cell Biol       Date:  2016-11-28       Impact factor: 4.272

9.  Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Authors:  Hongying Lin; Peter C Fridy; Anthony A Ribeiro; Jae H Choi; Deb K Barma; Günter Vogel; J R Falck; Stephen B Shears; John D York; Georg W Mayr
Journal:  J Biol Chem       Date:  2008-11-03       Impact factor: 5.157

10.  Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform.

Authors:  Ratnam S Seelan; Jaganathan Lakshmanan; Manuel F Casanova; Ranga N Parthasarathy
Journal:  J Biol Chem       Date:  2009-02-02       Impact factor: 5.157
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