Jessica H Baker1, Suzanne E Mazzeo, Kenneth S Kendler. 1. Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA. bakerjh@vcu.edu
Abstract
OBJECTIVE: Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD. METHOD: Participants included 490 monozygotic and 354 dizygotic female twins and 930 females from opposite sex pairs. Multiple logistic regression analyses were used to test shared correlates and mediators. Bivariate twin analyses were used to investigate the contribution of genes and environment to the correlation between BN and DUD. RESULTS: Depression, neuroticism, and childhood sexual abuse (CSA) mediated the association between BN and DUD regardless of which disorder was used as the dependent variable. Analyses also indicated genetic and nonshared environmental overlap between BN and DUD. CONCLUSION: The association between BN and DUD is due mostly to overlapping genetic influences with a smaller contribution from nonshared environment. Depression, neuroticism, and CSA are likely important shared correlates. (c) 2007 by Wiley Periodicals, Inc.
OBJECTIVE: Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD. METHOD:Participants included 490 monozygotic and 354 dizygotic female twins and 930 females from opposite sex pairs. Multiple logistic regression analyses were used to test shared correlates and mediators. Bivariate twin analyses were used to investigate the contribution of genes and environment to the correlation between BN and DUD. RESULTS:Depression, neuroticism, and childhood sexual abuse (CSA) mediated the association between BN and DUD regardless of which disorder was used as the dependent variable. Analyses also indicated genetic and nonshared environmental overlap between BN and DUD. CONCLUSION: The association between BN and DUD is due mostly to overlapping genetic influences with a smaller contribution from nonshared environment. Depression, neuroticism, and CSA are likely important shared correlates. (c) 2007 by Wiley Periodicals, Inc.
Authors: Melissa A Munn-Chernoff; Lauren R Few; Camden E Matherne; Jessica H Baker; Vera Yu Men; Vivia V McCutcheon; Arpana Agrawal; Kathleen K Bucholz; Pamela A F Madden; Andrew C Heath; Alexis E Duncan Journal: Drug Alcohol Depend Date: 2020-04-25 Impact factor: 4.492
Authors: Jessica H Baker; Nicole K Johnson; Melissa A Munn-Chernoff; Paul Lichtenstein; Henrik Larsson; Hermine H Maes; Kenneth S Kendler Journal: J Stud Alcohol Drugs Date: 2018-09 Impact factor: 2.582
Authors: Therese Killeen; Timothy D Brewerton; Aimee Campbell; Lisa R Cohen; Denise A Hien Journal: Am J Drug Alcohol Abuse Date: 2015-09-14 Impact factor: 3.829