Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum.

Literature DB >> 17851435

Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum.

Lin Zhang¹, Zhen-Huan Liu, Jing-Kui Tian.

Abstract

Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23alpha-tetrahydroxyoleanane-28(13)-lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17851435 PMCID： PMC6149337 DOI： 10.3390/12040832

Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411

22 in total

1. Two new triterpenoid saponins from Platycodon grandiflorum.

Authors: T Nikaido; K Koike; K Mitsunaga; T Saeki
Journal: Chem Pharm Bull (Tokyo) Date: 1999-06 Impact factor: 1.645

2. Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes.

Authors: Kwang Seok Ahn; Bum-Soo Hahn; Kyubum Kwack; Eun Bang Lee; Yeong Shik Kim
Journal: Eur J Pharmacol Date: 2006-03-20 Impact factor: 4.432

3. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice.

Authors: Hai Lin Zhao; Kyung-Hyun Cho; Young Wan Ha; Tae-Sook Jeong; Woo Song Lee; Yeong Shik Kim
Journal: Eur J Pharmacol Date: 2006-03-18 Impact factor: 4.432

4. Five new triterpenoid saponins from the roots of Platycodon grandiflorum.

Authors: Wen-Wei Fu; Noriko Shimizu; De-Qiang Dou; Tadahiro Takeda; Rui Fu; Yue-Hu Pei; Ying-Jie Chen
Journal: Chem Pharm Bull (Tokyo) Date: 2006-04 Impact factor: 1.645

5. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters.

Authors: Chan Young Shin; Woo Jong Lee; Eun Bang Lee; Eui Yul Choi; Kwang Ho Ko
Journal: Planta Med Date: 2002-03 Impact factor: 3.352

6. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.

Authors: Y P Kim; E B Lee; S Y Kim; D Li; H S Ban; S S Lim; K H Shin; K Ohuchi
Journal: Planta Med Date: 2001-06 Impact factor: 3.352

7. [Saponins of polygalacic acid type from Platycodon grandiflorum].

Authors: Wen-wei Fu; Wen-bin Hou; De-qiang Dou; Hui-ming Hua; Mao-hua Gui; Rui Fu; Ying-jie Chen; Yue-hu Pei
Journal: Yao Xue Xue Bao Date: 2006-04

8. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines.

Authors: Young Sup Kim; Jeoung Seob Kim; Sang-Un Choi; Jung Sook Kim; Hyun Sun Lee; Seong Hwan Roh; Young Chul Jeong; Young-Kyoon Kim; Shi Yong Ryu
Journal: Planta Med Date: 2005-06 Impact factor: 3.352

9. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells.

Authors: Kwang Seok Ahn; Eun Jung Noh; Hai Lin Zhao; Sang Hoon Jung; Sam Sik Kang; Yeong Shik Kim
Journal: Life Sci Date: 2005-04-01 Impact factor: 5.037

10. Triterpenoid saponins from Platycodon grandiflurum.

Authors: W-W Fu; D-Q Dou; C-J Zhao; N Shimizu; Y-P Pei; Y-H Pei; Y-J Chen; T Takeda
Journal: J Asian Nat Prod Res Date: 2007 Jan-Feb Impact factor: 1.569

6 in total

1. Whole-genome, transcriptome, and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus, a medicinal plant.

Authors: Jungeun Kim; Sang-Ho Kang; Sin-Gi Park; Tae-Jin Yang; Yi Lee; Ok Tae Kim; Oksung Chung; Jungho Lee; Jae-Pil Choi; Soo-Jin Kwon; Keunpyo Lee; Byoung-Ohg Ahn; Dong Jin Lee; Seung-Il Yoo; In-Gang Shin; Yurry Um; Dae Young Lee; Geum-Soog Kim; Chang Pyo Hong; Jong Bhak; Chang-Kug Kim
Journal: Hortic Res Date: 2020-07-01 Impact factor: 6.793

2. The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis.

Authors: Karel Miettinen; Jacob Pollier; Dieter Buyst; Philipp Arendt; René Csuk; Sven Sommerwerk; Tessa Moses; Jan Mertens; Prashant D Sonawane; Laurens Pauwels; Asaph Aharoni; José Martins; David R Nelson; Alain Goossens
Journal: Nat Commun Date: 2017-02-06 Impact factor: 14.919

3. Whole-genome, transcriptome, and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus, a medicinal plant.