AIM: To isolate triterpene saponins of polygalacic acid type from the roots of Platycodon grandiflorum (Jacq.) A. DC and to identify their structures. METHODS: The compounds were separated by means of extraction, chromatography on silica gel, MPLC and HPLC, and their structures were elucidated on the basis of spectral analyses (FAB-MS, IR, 1H NMR, 13C NMR etc.). RESULTS: Three triterpene saponins were isolated from the roots of Platycodon grandiflorum. They were identified as 3-O-beta-D-laminaribiosyl polygalacic acid (I), 3-O-beta-D-glucopyranosyl polygalacic acid (II), polygalacin D (III), separately. CONCLUSION: Compound I is a new compound, compounds II, III are known triterpene saponins. The compound I and II were isolated from the plant for the first time, which is also the monodesmoside from the plant for the first time.
AIM: To isolate triterpenesaponins of polygalacic acid type from the roots of Platycodon grandiflorum (Jacq.) A. DC and to identify their structures. METHODS: The compounds were separated by means of extraction, chromatography on silica gel, MPLC and HPLC, and their structures were elucidated on the basis of spectral analyses (FAB-MS, IR, 1H NMR, 13C NMR etc.). RESULTS: Three triterpenesaponins were isolated from the roots of Platycodon grandiflorum. They were identified as 3-O-beta-D-laminaribiosyl polygalacic acid (I), 3-O-beta-D-glucopyranosyl polygalacic acid (II), polygalacin D (III), separately. CONCLUSION: Compound I is a new compound, compounds II, III are known triterpenesaponins. The compound I and II were isolated from the plant for the first time, which is also the monodesmoside from the plant for the first time.
Authors: Ronald J Y Chen; Tse-yu Chung; Feng-yin Li; Wei-hung Yang; Tzyy-rong Jinn; Jason T C Tzen Journal: Acta Pharmacol Sin Date: 2010-06 Impact factor: 6.150
Authors: Ronald J Y Chen; Tzyy-rong Jinn; Yi-ching Chen; Tse-yu Chung; Wei-hung Yang; Jason T C Tzen Journal: Acta Pharmacol Sin Date: 2011-02 Impact factor: 6.150