Literature DB >> 17850210

Hypoxia-induced signaling in the cardiovascular system.

M Celeste Simon1, Liping Liu, Bryan C Barnhart, Regina M Young.   

Abstract

Low oxygen (O2) levels are a naturally occurring feature of embryonic development, adult physiology, and diseases such as those of the cardiovascular system. Although many responses to O2 deprivation are mediated by hypoxia-inducible factors (HIFs), researchers are finding a growing number of HIF-independent pathways that promote O2 conformance and hypoxia tolerance. Here, we describe HIF-independent responses and how they impact cardiovascular tissue homeostasis.

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Year:  2008        PMID： 17850210      PMCID： PMC2871679          DOI： 10.1146/annurev.physiol.70.113006.100526

Source DB:  PubMed          Journal:  Annu Rev Physiol        ISSN： 0066-4278            Impact factor:   19.318


  94 in total

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  30 in total

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