| Literature DB >> 17846563 |
Naoko Togashi1, Akiko Shiraishi, Miki Nishizaka, Keisuke Matsuoka, Kazutoyo Endo, Hajime Hamashima, Yoshihiro Inoue.
Abstract
The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.Entities:
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Year: 2007 PMID： 17846563 PMCID： PMC6149398 DOI： 10.3390/12020139
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411