Literature DB >> 17838112

Attenuation of Aversive Properties of Peripheral Shock by Hypothalamic Stimulation.

V C Cox, E S Valenstein.   

Abstract

Clinical reports of alleviation of pain with positive brain stimulation were investigated experimnentally. Rats in a two-compartment testing chamber sought out hypothalamic stimulation and escaped from aversive foot shock delivered through a grid-scrambling device. Animals also sought out paired hypothalamic stimulation and foot shock. Control experiments demonstrating that animals did not discriminate between hypothalamic stimulcation and paired hypothalamic stimulation and foot shock supported the view that hypothalamic stimulation attenuates the aversive properties of foot shock.

Entities:  

Year:  1965        PMID： 17838112     DOI： 10.1126/science.149.3681.323

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Food and intracranial stimulation responding suppressed with regular-interval shock.

Authors:  E Schmidt; M McCaleb; H K Merrill
Journal:  J Exp Anal Behav       Date:  1977-01       Impact factor: 2.468

2.  Interaction between morphine and reinforcing lateral hypothalamic stimulation.

Authors:  K Ornstein; J P Huston
Journal:  Psychopharmacology (Berl)       Date:  1977-11-15       Impact factor: 4.530

3.  Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonist.

Authors:  Conan Kornetsky; Clifford M Knapp; Lisa Tozier; Arlene Pak
Journal:  Pharmacol Biochem Behav       Date:  2010-02-10       Impact factor: 3.533

Review 4.  Deep brain stimulation for chronic pain: intracranial targets, clinical outcomes, and trial design considerations.

Authors:  Orion Paul Keifer; Jonathan P Riley; Nicholas M Boulis
Journal:  Neurosurg Clin N Am       Date:  2014-10       Impact factor: 2.509

5.  Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.

Authors:  Shogo Tashiro; Ran Yamaguchi; Sodemi Ishikawa; Takeshi Sakurai; Katsuko Kajiya; Yuichi Kanmura; Tomoyuki Kuwaki; Hideki Kashiwadani
Journal:  Sci Rep       Date:  2016-11-15       Impact factor: 4.379

6.  Changes in median eminence of fatty acid-binding protein 3 in a mouse model of pain.

Authors:  Dan Tachibana; Kazuo Nakamoto; Shogo Tokuyama
Journal:  Neuropsychopharmacol Rep       Date:  2022-01-28

7.  Precision Medicine in Alzheimer's Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity.

Authors:  Maria Grazia Morgese; Maria Bove; Lorenzo Di Cesare Mannelli; Stefania Schiavone; Anna Laura Colia; Stefania Dimonte; Emanuela Mhillaj; Vladyslav Sikora; Paolo Tucci; Carla Ghelardini; Luigia Trabace
Journal:  Front Pharmacol       Date:  2022-01-03       Impact factor: 5.810
  7 in total

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