Literature DB >> 17828485

Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha.

Xiuping Liu1, Changyun Xiong, Chunhong Li, Deguang Yang.   

Abstract

Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.

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Year:  2007        PMID： 17828485     DOI： 10.1007/s11596-007-0402-9

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  18 in total

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  1 in total

1.  Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells.

Authors:  Xiuping Liu; Yumei Zuo; Weina Zhang; Deguang Yang; Changyun Xiong; Xiaozhou Zhang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2009-10-11
  1 in total

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