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Literature DB >> 17826993

5'-halogenated analogs of oxymorphindole.

Abstract

The presence of a 6,7-fused indole group in the indolomorphinans was considered to be responsible for the delta opioid selectivity for this class of ligands. Herein is shown that 5'-halogenated analogs of oxymorphindole are opioids with little selectivity for delta receptors over mu opioid receptors.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17826993 PMCID： PMC2062523 DOI： 10.1016/j.bmcl.2007.07.098

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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References

10 in total

1. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.

Authors: A Coop; R B Rothman; C Dersch; J Partilla; F Porreca; P Davis; A E Jacobson; K C Rice
Journal: J Med Chem Date: 1999-05-06 Impact factor: 7.446

Review 2. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics.

Authors: Subramaniam Ananthan
Journal: AAPS J Date: 2006-03-10 Impact factor: 4.009

3. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

Authors: E E Abdelhamid; M Sultana; P S Portoghese; A E Takemori
Journal: J Pharmacol Exp Ther Date: 1991-07-01 Impact factor: 4.030

4. Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.

Authors: S Ananthan; H S Kezar; R L Carter; S K Saini; K C Rice; J L Wells; P Davis; H Xu; C M Dersch; E J Bilsky; F Porreca; R B Rothman
Journal: J Med Chem Date: 1999-09-09 Impact factor: 7.446

5. The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.

Authors: P W Schiller; M E Fundytus; L Merovitz; G Weltrowska; T M Nguyen; C Lemieux; N N Chung; T J Coderre
Journal: J Med Chem Date: 1999-09-09 Impact factor: 7.446

5'-halogenated analogs of oxymorphindole.

1. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.

Review 2. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics.

3. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

4. Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.

5. The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.

6. N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.

7. Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.

Review 8. Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance.

9. Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole.

10. Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone.