Literature DB >> 17825917

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

Christian R Kowol1, Rene Eichinger, Michael A Jakupec, Markus Galanski, Vladimir B Arion, Bernhard K Keppler.   

Abstract

Three chalcogensemicarbazones, viz., 2-acetylpyridine N,N-dimethylsemicarbazone (HL(1)), 2-acetylpyridine N,N-dimethylthiosemicarbazone (HL(2)) and 2-acetylpyridine N,N-dimethylselenosemicarbazone (HL(3)), their corresponding gallium(III) complexes [Ga(L(1-3))(2)]PF(6) and the ruthenium(III) compound [Ru(L(2))(2)]PF(6) have been prepared and characterised by X-ray crystallography and spectroscopic techniques (IR, UV/vis, (1)H, (13)C, (15)N, (77)Se NMR) in order to elucidate the effect of metal ion complexation and chalcogen donor identity on the cytotoxicity of chalcogensemicarbazones in two human tumour cell lines 41M (ovarian carcinoma) and SK-BR-3 (mammary carcinoma).

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Year:  2007        PMID： 17825917     DOI： 10.1016/j.jinorgbio.2007.07.026

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  12 in total

1.  Molecular docking, PASS analysis, bioactivity score prediction, synthesis, characterization and biological activity evaluation of a functionalized 2-butanone thiosemicarbazone ligand and its complexes.

Authors:  Tahmeena Khan; Shalini Dixit; Rumana Ahmad; Saman Raza; Iqbal Azad; Seema Joshi; Abdul Rahman Khan
Journal:  J Chem Biol       Date:  2017-04-04

2.  Bis(ethanol-κO)bis-(pyridine-3-carb-aldehyde-κN thio-semicarbazone)bis-(thio-cyanato-κN)iron(II)-pyridine-3-carbaldehyde thio-semicarbazone (1/2).

Authors:  Shao-Mei Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-01

3.  Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration.

Authors:  Biao Hu; Bo Wang; Bing Zhao; Qian Guo; Zhong-Hua Li; Xin-Hui Zhang; Guang-Yao Liu; Ying Liu; Ying Tang; Fan Luo; Ya Du; Ya-Xin Chen; Li-Ying Ma; Hong-Min Liu
Journal:  Medchemcomm       Date:  2017-10-23       Impact factor: 3.597

4.  Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells.

Authors:  Felipe S Pessoto; Cesar H Yokomizo; Tatiana Prieto; Cleverton S Fernandes; Alan P Silva; Carlos R Kaiser; Ernani A Basso; Iseli L Nantes
Journal:  Oxid Med Cell Longev       Date:  2015-05-05       Impact factor: 6.543

5.  Copper(II) Thiosemicarbazone Complexes and Their Proligands upon UVA Irradiation: An EPR and Spectrophotometric Steady-State Study.

Authors:  Michal Hricovíni; Milan Mazúr; Angela Sîrbu; Oleg Palamarciuc; Vladimir B Arion; Vlasta Brezová
Journal:  Molecules       Date:  2018-03-21       Impact factor: 4.411

6.  Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters.

Authors:  Miljan N M Milunović; Oleg Palamarciuc; Angela Sirbu; Sergiu Shova; Dan Dumitrescu; Dana Dvoranová; Peter Rapta; Tatsiana V Petrasheuskaya; Eva A Enyedy; Gabriella Spengler; Marija Ilic; Harald H Sitte; Gert Lubec; Vladimir B Arion
Journal:  Biomolecules       Date:  2020-08-20

7.  (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines.

Authors:  Tamara R Todorović; Jelena Vukašinović; Gustavo Portalone; Sherif Suleiman; Nevenka Gligorijević; Snezana Bjelogrlić; Katarina Jovanović; Siniša Radulović; Katarina Anđelković; Analisse Cassar; Nenad R Filipović; Pierre Schembri-Wismayer
Journal:  Medchemcomm       Date:  2016-10-20       Impact factor: 3.597

8.  Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities.

Authors:  Yu-Ting Wang; Yan Fang; Meng Zhao; Ming-Xue Li; Yu-Mei Ji; Qiu-Xia Han
Journal:  Medchemcomm       Date:  2017-10-09       Impact factor: 3.597

9.  A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells.

Authors:  Hongtao Shen; Haichuan Zhu; Mowei Song; Yonglu Tian; Yafei Huang; Hui Zheng; Ruiyuan Cao; Jian Lin; Zhenggang Bi; Wu Zhong
Journal:  BMC Cancer       Date:  2014-08-29       Impact factor: 4.430

10.  Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.

Authors:  Karla Pelivan; Lisa M Frensemeier; Uwe Karst; Gunda Koellensperger; Petra Heffeter; Bernhard K Keppler; Christian R Kowol
Journal:  Anal Bioanal Chem       Date:  2018-02-23       Impact factor: 4.142
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