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Literature DB >> 17825826

Localization and regulation of mouse pantothenate kinase 2.

Roberta Leonardi¹, Yong-Mei Zhang, Athanasios Lykidis, Charles O Rock, Suzanne Jackowski.

Abstract

Coenzyme A (CoA) biosynthesis is initiated by pantothenate kinase (PanK) and CoA levels are controlled through differential expression and feedback regulation of PanK isoforms. PanK2 is a mitochondrial protein in humans, but comparative genomics revealed that acquisition of a mitochondrial targeting signal was limited to primates. Human and mouse PanK2 possessed similar biochemical properties, with inhibition by acetyl-CoA and activation by palmitoylcarnitine. Mouse PanK2 localized in the cytosol, and the expression of PanK2 was higher in human brain compared to mouse brain. Differences in expression and subcellular localization should be considered in developing a mouse model for human PanK2 deficiency.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2007 PMID： 17825826 PMCID： PMC2034339 DOI： 10.1016/j.febslet.2007.08.056

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

22 in total

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7. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.

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