BACKGROUND:Conjugated linoleic acid (CLA) is a family of positional and geometric isomers with 2 conjugated double bonds formed from linoleic acid and linolenic acid. CLA has a wide range of biological effects, including body fat reduction. OBJECTIVE: The aim of our study was to determine CLA's effects on energy expenditure, macronutrient utilization, and dietary fat oxidation in overweight adults after 6 mo of supplementation. DESIGN: We recruited 23 subjects from our main CLA efficacy study who were receiving either 4 g/d of 78% active CLA isomers (3.2 g/d: 39.2% cis-9,trans-11 and 38.5% trans-10,cis-12) or 4 g/d ofsafflower oil. Energy expenditure and substrate utilization were measured before and after 6 mo of CLA supplementation by using whole-room indirect calorimetry. Dietary fat oxidation was measured by using stable isotope-labeled oleate and palmitate. RESULTS: Our substudy detected a difference in the change in fat utilization between the CLA (4 +/- 8 g) and placebo (-7 +/- 11 g) groups during sleep after 6 mo of supplementation. In addition, the percentage of energy from protein was reduced during sleep in the CLA group (CLA: -3.3 +/- 2.6%; placebo: 0.3 +/- 5.7%). We also detected a difference in the change in energy expenditure during sleep (CLA: 0 +/- 38 kcal; placebo: -43 +/- 90 kcal). We did not detect a change in labeled dietary fat oxidation after 6 mo of CLA supplementation given with a breakfast meal. CONCLUSION: Mixed isomer CLA supplementation, but not placebo, positively altered fat oxidation and energy expenditure during sleep.
RCT Entities:
BACKGROUND: Conjugated linoleic acid (CLA) is a family of positional and geometric isomers with 2 conjugated double bonds formed from linoleic acid and linolenic acid. CLA has a wide range of biological effects, including body fat reduction. OBJECTIVE: The aim of our study was to determine CLA's effects on energy expenditure, macronutrient utilization, and dietary fat oxidation in overweight adults after 6 mo of supplementation. DESIGN: We recruited 23 subjects from our main CLA efficacy study who were receiving either 4 g/d of 78% active CLA isomers (3.2 g/d: 39.2% cis-9,trans-11 and 38.5% trans-10,cis-12) or 4 g/d of safflower oil. Energy expenditure and substrate utilization were measured before and after 6 mo of CLA supplementation by using whole-room indirect calorimetry. Dietary fat oxidation was measured by using stable isotope-labeled oleate and palmitate. RESULTS: Our substudy detected a difference in the change in fat utilization between the CLA (4 +/- 8 g) and placebo (-7 +/- 11 g) groups during sleep after 6 mo of supplementation. In addition, the percentage of energy from protein was reduced during sleep in the CLA group (CLA: -3.3 +/- 2.6%; placebo: 0.3 +/- 5.7%). We also detected a difference in the change in energy expenditure during sleep (CLA: 0 +/- 38 kcal; placebo: -43 +/- 90 kcal). We did not detect a change in labeled dietary fat oxidation after 6 mo of CLA supplementation given with a breakfast meal. CONCLUSION: Mixed isomer CLA supplementation, but not placebo, positively altered fat oxidation and energy expenditure during sleep.
Authors: Corinne Malpuech-Brugère; Ronald P Mensink; Olivier Loreau; Agnès Maret; Claire E Fernie; Taous S Lassel; Jean Michel Chardigny; Charlie M Scrimgeour; Jean Louis Sébédio; Bernard Beaufrère Journal: Lipids Date: 2010-10-09 Impact factor: 1.880
Authors: Robert S Chapkin; David N McMurray; Laurie A Davidson; Bhimanagouda S Patil; Yang-Yi Fan; Joanne R Lupton Journal: Br J Nutr Date: 2008-05-20 Impact factor: 3.718
Authors: Laura J den Hartigh; Shari Wang; Leela Goodspeed; Tomasz Wietecha; Barbara Houston; Mohamed Omer; Kayoko Ogimoto; Savitha Subramanian; G A Nagana Gowda; Kevin D O'Brien; Karl J Kaiyala; Gregory J Morton; Alan Chait Journal: PLoS One Date: 2017-02-28 Impact factor: 3.240
Authors: Karen J Murphy; Georgina E Crichton; Kathryn A Dyer; Alison M Coates; Tahna L Pettman; Catherine Milte; Alicia A Thorp; Narelle M Berry; Jonathan D Buckley; Manny Noakes; Peter R C Howe Journal: Nutrients Date: 2013-11-20 Impact factor: 5.717