Literature DB >> 17822301

Parallel solution-phase synthesis of 2-alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by one-pot three-component domino reaction.

Stéven Renault1, Sarah Bertrand, François Carreaux, Jean Pierre Bazureau.   

Abstract

A practical protocol for the preparation of a parallel solution-phase library of 5-arylidene imidazolone is reported. Target compounds were obtained in good yield, stereoselectively, and purity by one-pot domino reaction from various thiohydantoines, arylaldimines, and halogenoalkanes. Purification of the final products by recrystallization with a mixture of pentane/ethanol allowed simple isolation of the 17 components of the array.

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Year:  2007        PMID： 17822301     DOI： 10.1021/cc070022i

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  3 in total

1.  5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Authors:  Venkata Ramana Sirivolu; Sanjeev Kumar V Vernekar; Christophe Marchand; Alena Naumova; Adel Chergui; Amelie Renaud; Andrew G Stephen; Feng Chen; Yuk Y Sham; Yves Pommier; Zhengqiang Wang
Journal:  J Med Chem       Date:  2012-10-08       Impact factor: 7.446

2.  Crystal structure of 8-[7,8-bis-(4-chloro-benzo-yl)-7H-cyclo-penta-[a]ace-naphthylen-9-yl]naphthalene-1-carb-oxy-lic acid.

Authors:  Jomon P Jacob; M Sithambaresan; Christy Kunjachan; M R Prathapachandra Kurup
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-01

3.  A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives.

Authors:  Khadidja Bourahla; Ludovic Paquin; Olivier Lozach; Laurent Meijer; François Carreaux; Jean Pierre Bazureau
Journal:  Molecules       Date:  2011-08-30       Impact factor: 4.411
  3 in total

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