Literature DB >> 17805965

Role of ubiquitin protein ligases in the pathogenesis of polyglutamine diseases.

Priyanka Dikshit1, Nihar Ranjan Jana.   

Abstract

The accumulation of intracellular protein deposits as inclusion bodies is the common pathological hallmark of most age related neurodegenerative disorders including polyglutamine diseases. Appearances of aggregates of the misfolded mutant disease proteins suggest that the cells are unable to efficiently degrade them, and failure of clearance leads to the severe disturbances of the cellular quality control system. The quality control ubiquitin ligases are now increasingly implicated in the biology of polyglutamine diseases, Parkinson's diseases, Amyotrophic lateral sclerosis and Alzheimer's disease. Here we review the recent studies that have revealed a critical role of E3 ubiquitin ligases in understanding the pathogenesis of polyglutamine diseases.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17805965     DOI： 10.1007/s11064-007-9459-x

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  66 in total

1.  Protein quality control: chaperones culling corrupt conformations.

Authors:  Amie J McClellan; Stephen Tam; Daniel Kaganovich; Judith Frydman
Journal:  Nat Cell Biol       Date:  2005-08       Impact factor: 28.824

Review 2.  The ubiquitin system.

Authors:  A Hershko; A Ciechanover
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

3.  CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Authors:  Ismael Al-Ramahi; Yung C Lam; Hung-Kai Chen; Beatrice de Gouyon; Minghang Zhang; Alma M Pérez; Joana Branco; Maria de Haro; Cam Patterson; Huda Y Zoghbi; Juan Botas
Journal:  J Biol Chem       Date:  2006-07-10       Impact factor: 5.157

4.  The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

Authors:  Youngah Shin; Jochen Klucken; Cam Patterson; Bradley T Hyman; Pamela J McLean
Journal:  J Biol Chem       Date:  2005-04-21       Impact factor: 5.157

5.  The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation.

Authors:  G C Meacham; C Patterson; W Zhang; J M Younger; D M Cyr
Journal:  Nat Cell Biol       Date:  2001-01       Impact factor: 28.824

6.  Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.

Authors:  N R Jana; M Tanaka; G h Wang; N Nukina
Journal:  Hum Mol Genet       Date:  2000-08-12       Impact factor: 6.150

7.  Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

Authors:  C J Cummings; M A Mancini; B Antalffy; D B DeFranco; H T Orr; H Y Zoghbi
Journal:  Nat Genet       Date:  1998-06       Impact factor: 38.330

8.  U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.

Authors:  Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Miyuki Murayama; Du-Hua Chui; Emmanuel Planel; Ryosuke Takahashi; Keiichi I Nakayama; Akihiko Takashima
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

9.  CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

Authors:  Victor M Miller; Rick F Nelson; Cynthia M Gouvion; Aislinn Williams; Edgardo Rodriguez-Lebron; Scott Q Harper; Beverly L Davidson; Michael R Rebagliati; Henry L Paulson
Journal:  J Neurosci       Date:  2005-10-05       Impact factor: 6.709

Review 10.  Dysfunction of wild-type huntingtin in Huntington disease.

Authors:  Elena Cattaneo
Journal:  News Physiol Sci       Date:  2003-02
View more
  2 in total

Review 1.  Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.

Authors:  Márcio S Baptista; Carlos B Duarte; Patrícia Maciel
Journal:  Cell Mol Life Sci       Date:  2012-03-03       Impact factor: 9.261

2.  Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1.

Authors:  Jorgelina M Calandria; Pranab K Mukherjee; Juan Carlos de Rivero Vaccari; Min Zhu; Nicos A Petasis; Nicolas G Bazan
Journal:  J Biol Chem       Date:  2012-04-16       Impact factor: 5.157
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.