Literature DB >> 12531930

Dysfunction of wild-type huntingtin in Huntington disease.

Elena Cattaneo1.   

Abstract

Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD.

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Year:  2003        PMID： 12531930     DOI： 10.1152/nips.01410.2002

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  10 in total

Review 1.  Epigenetic mechanisms of neurodegeneration in Huntington's disease.

Authors:  Junghee Lee; Yu Jin Hwang; Ki Yoon Kim; Neil W Kowall; Hoon Ryu
Journal:  Neurotherapeutics       Date:  2013-10       Impact factor: 7.620

2.  Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's disease.

Authors:  Surekha Ramachandran; Sumathi Thangarajan
Journal:  Metab Brain Dis       Date:  2018-05-31       Impact factor: 3.584

Review 3.  Role of ubiquitin protein ligases in the pathogenesis of polyglutamine diseases.

Authors:  Priyanka Dikshit; Nihar Ranjan Jana
Journal:  Neurochem Res       Date:  2007-09-01       Impact factor: 3.996

4.  Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies.

Authors:  Claudia Riccardi; Federica D'Aria; Filomena Anna Digilio; Maria Rosaria Carillo; Jussara Amato; Dominga Fasano; Laura De Rosa; Simona Paladino; Mariarosa Anna Beatrice Melone; Daniela Montesarchio; Concetta Giancola
Journal:  Int J Mol Sci       Date:  2022-04-27       Impact factor: 6.208

5.  Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2.

Authors:  Edoardo Marcora; Katherine Gowan; Jacqueline E Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-24       Impact factor: 11.205

Review 6.  Nucleolar dysfunction in Huntington's disease.

Authors:  Junghee Lee; Yu Jin Hwang; Hyun Ryu; Neil W Kowall; Hoon Ryu
Journal:  Biochim Biophys Acta       Date:  2013-10-31

7.  CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease.

Authors:  Nivya Kolli; Ming Lu; Panchanan Maiti; Julien Rossignol; Gray L Dunbar
Journal:  Int J Mol Sci       Date:  2017-04-02       Impact factor: 5.923

Review 8.  3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.

Authors:  Isaac Túnez; Inmaculada Tasset; Verónica Pérez-De La Cruz; Abel Santamaría
Journal:  Molecules       Date:  2010-02-10       Impact factor: 4.411

9.  MicroRNA editing patterns in Huntington's disease.

Authors:  Shiyong Guo; Jun Yang; Bingbing Jiang; Nan Zhou; Hao Ding; Guangchen Zhou; Shuai Wu; Angbaji Suo; Xingwang Wu; Wenping Xie; Wanran Li; Yulong Liu; Wei Deng; Yun Zheng
Journal:  Sci Rep       Date:  2022-02-24       Impact factor: 4.379

Review 10.  BDNF signaling and survival of striatal neurons.

Authors:  Maryna Baydyuk; Baoji Xu
Journal:  Front Cell Neurosci       Date:  2014-08-28       Impact factor: 5.505
  10 in total

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